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Islamically Permissible COVID-19 Vaccines: Viral Vector Page

Prepared by Mawlana Mateen A. Khan MD, Dr. Ramzan Judge PharmD, Dr. Samad Tirmizi PharmD, and Mufti Adil Farooki MD.

Summary:

Oxford-AstraZeneca and Janssen (Johnson & Johnson) COVID-19 vaccines are ḥalāl and permissible for use although other vaccines without ethical issues (e.g., mRNA vaccines) are preferable when available.

Summary page for all assessed COVID-19 vaccines

Oxford-AstraZeneca Discussion:

The University of Oxford partnered with AstraZeneca to develop a viral vector vaccine, called ChAdOx1 nCov-19 or AZD1222. It consists of a chimpanzee adenovirus vector (ChAdOx1) which has been rendered incapable of replication. The adenovirus contains DNA which encodes for the full-length SARS-CoV-2 spike protein.[i] This modified adenovirus is produced within HEK293 cells. The HEK293 cell line are the offspring cells originating from normal human embryonic kidney (HEK) cells made to replicate indefinitely in 1973. Since then, they have been grown in artificial media throughout laboratories across the world. They were obtained initially from a single, healthy fetus. The status of this fetus, whether obtained via spontaneous miscarriage or elective abortion, remains unclear.[ii] Once the adenovirus is produced in sufficient quantity within the HEK293 cells, the cells are lysed. The adenovirus containing spike protein DNA is purified from the resultant solution and cell products. These adenoviruses make up the active component of the Oxford-AstraZeneca vaccine. Other excipients, including ethanol, compose the rest of the vaccine.

This process raises several issues of concern for Muslims[1]:

  • Use of fetal bovine serum (FBS) in HEK293 cell culture media
  • Permissibility and Purity of Human cells
  • Ongoing use of HEK293 cells in research and production
  • Use of synthetic ethanol as an excipient

Each one of these issues will be addressed in order before giving a final ruling on the Oxford-AstraZeneca Vaccine.

Use of Fetal Bovine Serum

Oxford-AstraZeneca’s production makes use of fetal bovine serum (FBS) in the HEK293 cell culture media.[iii] Cells, which are propagated outside of a body, require nutrients and other factors. FBS provides these nutrients and factors and is therefore a common component of animal cell culture media. When a cow is sent for industrial processing, it is eviscerated at the time of slaughtering. The reproductive organs and tract are sent to a calf processing area. If the uterus is found to contain a fetus, the fetus is cleaned, its heart punctured through the rib cage, and blood subsequently drained. Serum is later separated from the drained blood.[iv]

Allah, the Exalted, says, “Do not eat from that upon which Allah’s name has not been mentioned,” and “Indeed, He has forbidden dead animals and blood.”[v] In all likelihood, these cows are slaughtered in a way rendering them impermissible (ḥarām) to consume and impure (najis). They are both those upon which Allah’s name has not been mentioned at the time of slaughtering and without a proper slaughtering, that which is considered dead. Likewise, the bovine fetus and its blood are impermissible and impure as stated in the verse above. [vi] This ruling extends to the serum extracted from it.

Despite the ethical and juristic problems posed by this process, the FBS is completely separated from the final vaccine product in a series of purification steps rendering the final product free of any serum components.[vii]

Cells from an aborted human fetus

Permissibility

A set of human embryonic kidney cells, the parent HEK293 cells, were initially obtained from a human fetus in 1973. Allah, the Exalted, states, “Indeed, we have honored the children of Ādam.” (Surah al-Isrā’: 70) These few words, indicating the special status of humans above all other creations, have far reaching implications. Among them, the fuqahā’ have derived the general impermissibility of using human parts.[viii]

They have included in this impermissibility minor parts, like fingernails, and extended it to even situations of extreme need, like cannibalism in the face of death by starvation. Thus, the general principle of the verse and rulings extends to all human cells, including the aforementioned human embryonic kidney cells. Hypothetically, if it was permissible in cases of extreme need (ḍarūrah), at the time of harvesting the parent HEK293 cells, no particular need was present. It is also uncertain if the fetus was aborted in a matter that was spontaneous, permissible, or impermissible in the Sharī`ah, which further clouds any potential permissibility of its use.

Purity

Allah, the Exalted, states, “(O Prophet ﷺ) say, ‘I do not find, in what was revealed to me, (anything) forbidden from what is eaten except a dead animal, flowing blood, or the flesh of swine. Indeed, it is impure (rijs).’” (Surah al-An`ām: 145) The word rijs comes in the meaning of najis, that which is impure. Similarly, Allah, the Exalted, states, “[Allah] has only forbidden to you the dead animal, blood, the flesh of swine, and that which has been dedicated to other than Allah.” (Surah al-Baqarah: 173) From these two verses and numerous narrations, the fuqahā’ have derived the rulings of najis and ḥarām of any removed parts of a deceased human that contained flowing blood at one point.[ix] Likewise, these rulings also extend to human embryonic kidney cells.

Ongoing use of HEK293 cells in research and production

As stated, the parent cells of the HEK293 cell line were extracted almost fifty years ago. Since then, they have undergone countless replication cycles. Do the same rulings apply to the cell line as applied to the parent embryonic kidney cells? If they do not, what about the offspring cells makes them sufficiently different than their parent cells to necessitate a different ruling? Also, at one point in time in the replication process did the ruling change? In answer to these questions, we note several points which indicate the cell line incurs the same rulings as the initial cells:

  • Although there have been slight modifications to the HEK293 DNA, for the most part, the cells continue to appear and behave as the parent cells. In fact, this is the primary reason for their continued use in laboratories – they appear and act as normal human cells – allowing scientists to experiment on human cells without having to experiment on human beings.
  • In some respects, calling them offspring is a misnomer. Offspring generally differ from their parents in some way. However, cell lines do not significantly differ. They are merely an increase in the parent cells, more akin to growth of tissue than progeny.[x]
  • Most human cells within the body are constantly being replaced. The person today is no longer the same person cellularly that he was twenty years ago. Even though he is today the offspring cells of yesterday, the rulings of the Sharī`ah and worldly governance apply the same. For example, his marriage of twenty years ago or his debts.
  • For arguments sake, if we consider the cell line to be a different category than the initial cells, at one point did this change occur? Was it with the first replication or the billionth? Without a clear demarcation, it is unclear how or when one would apply a different ruling.

According to the jurstic principles, al-aṣl baqā’un mā kāna `ala mā kān and al-mutawallad min al-aṣl yakūnu bi ṣifah al-aṣl, consideration will be given to the original, known state until a sufficient cause to change is established.[xi] Hence, the HEK293 stem line retains the rulings of impermissibility of use, impurity, and impermissibility of consumption from the “parent” human embryonic cells.

Ruling of AZD1222

Normally, adenoviruses follow a lytic cycle in the human body in which:

  • A virus particle(s) injects genetic material into a cell.
  • The cell’s resources and machinery are hijacked for the purpose of replicating the viral genetic material and packaging.
  • Once sufficient levels of virus are replicated, the cell is broken open, and the viruses escape to begin this cycle anew.
Figure: Viral Lytic Cycle

As outlined above, the adenovirus vector AZD1222 is produced within the HEK293 cell line. Although in an industrial setting, this process is not fundamentally different than what takes place naturally. During production of the Oxford-AstraZeneca vaccine:

  • Viral DNA is injected into a cell of the cell line
  • The cell’s resources and machinery are hijacked for the purpose of replicating the viral genetic material and packaging.
  • Once sufficient levels of virus are replicated, the infected HEK293 are lysed chemically causing release of the replicated adenoviruses.
  • The adenoviruses are separated and purified from HEK293 remnants and growth medium.

In the understanding and terminology of laypeople and microbiologists, viruses are distinctly different from cells. Although assembled within the cell, the adenovirus is a separate entity, consisting mostly of genetic material and proteins. It is not thought of as a cell’s progeny nor is it thought to have life like the cell. Rather, it is a parasitic entity released from within the cell after having used it for replication. Herein lies the difference between the stem cell line and the adenovirus. Although both are born (mutawallad) of a cell, the stem cell line is a continuation of the original cells, while the adenovirus is a distinctly different entity. Hence, the stem cells retain the same juristic rulings as the initial HEK cells, whereas the adenoviruses do not. Additionally, the adenovirus is comparable to the example of a parasite born within the human body as mentioned in juristic texts.[xii] Like these parasites, the adenoviruses do not carry the same impure status or prohibition of its host, but rather, by default, they are pure (ṭāhir) and permissible to use.

Next, although the virus is born of a comparable process, it is, in its essence, unlike a parasite. Most parasites (e.g., intestinal worms) are from the khabā’ith, and the Qur’an has made them specifically impermissible to consume (ḥarām).[xiii] However, as microscopic collections of proteins and genetic material, viruses are not from this category, and by default, they are permissible to consume (ḥalāl). Thus, these adenoviruses, although derived from an impermissible and impure cell line, are permissible to use and pure.

Use of Ethanol as an Excipient

The Oxford-AstraZeneca vaccine contains the following excipients:

  • L-histidine
  • L-histidine hydrochloride monohydrate
  • magnesium chloride hexahydrate
  • polysorbate 80
  • ethanol
  • sucrose
  • sodium chloride
  • disodium edetate dihydrate

None of the vaccine’s excipients are animal derived. The list of excipients includes ethanol or ethyl alcohol. Ethanol has the potential for being impermissible (arām) if it is derived from khamr (fermented from dates or grapes) or has the potential to intoxicate. As evidenced by Allah’s, the Exalted, words, “O Believers, indeed khamr, gambling, altars and divining arrows are filth (rijs), made by Shayṭān. Therefore, refrain from it, so that you may be successful.” (Al-Mā’idah 90). Ethanol used in the vaccine is synthetically made and not derived from khamr. Additionally, it is found in exceedingly small amounts (0.002 g per dose of 0.5 ml vaccine)[xiv] such that intoxication is impossible. Therefore, the ethanol found in the vaccine is not of concern for Muslims.[xv]

Summary

The Oxford-AstraZeneca vaccine poses several ethical dilemmas throughout its manufacturing process including the impermissible use of human stem cell lines. These issues highlight the need for Muslims in the sector to exert influence in choosing processes in line with Islamic guidelines of permissibility and purity. Undoubtedly, following such guidelines will result in increased therapeutic benefit for everyone.

In conclusion, the resulting vaccine is permissible for use although other vaccines without ethical issues (e.g., mRNA vaccines) are preferable when available.

Acknowledgements: We would like to acknowledge the valuable feedback provided by Muftis Faisal al-Mahmudi (Canada), Omar Baig (Canada), Muhammad Faeq (Pakistan), Yusuf Shabbir (UK), and Amjad Mohammed (UK). May Allah ta`āla increase them in knowledge and accept them.


Janssen (Johnson & Johnson) Vaccine Discussion

Janssen in conjunction with Johnson & Johnson has developed a viral vector vaccine. The process utilized is similar in many respects including derivation from human fetal retinal cells, use of their progeny cells in the form of a stem line (PER.C6), and delivery via an adenovirus. Thus, this vaccine shares many of the issues of the Oxford-AstraZeneca vaccine.

Ingredients found in the vaccine are: recombinant, replication-incompetent adenovirus type 26 expressing the SARS-CoV-2 spike protein, citric acid monohydrate, trisodium citrate dihydrate, ethanol, 2-hydroxypropyl-β-cyclodextrin (HBCD), polysorbate-80, sodium chloride. These are non-animal derived.

For a discussion of these issues, please read the above detailed write-up on the Oxford-AstraZeneca vaccine. In conclusion, the resulting vaccine is permissible for use although other vaccines without ethical issues (e.g., mRNA vaccines) are preferable when available.


[1] Two other potential issues are not addressed here as they were felt to be peripheral and not directly related to the vaccine production. First, in preparing the HEK293 cells used in the production of this vaccine, another modified cell line T-Rex-293 was developed through the use of porcine trypsin. The trypsin was not in direct contact with the actual cell bank used in this manufacturing process. Second, the adenovirus vector (ChAdOx1) is a chimpanzee virus. For reasons that will become apparent in the article, the virus does not carry the same ruling as the chimpanzee cells from which it is derived.


[i] Chung, YH et al. COVID-19 Vaccine Frontrunners and Their Nanotechnology Design.

Folegatti, PM et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.

Morris, SJ et al. Laboratory-Scale Production of Replication-Deficient Adenovirus Vectored Vaccines.

Email correspondence with AstraZeneca (ref: F-632787, INQ 05503763), 15-Jan-2021

[ii] https://en.wikipedia.org/wiki/HEK_293_cells

https://www.thepublicdiscourse.com/2020/05/63752/

[iii] Morris, SJ et al. Laboratory-Scale Production of Replication-Deficient Adenovirus Vectored Vaccines.

[iv] Jochems, CEA et al. The Use of Fetal Bovine Serum: Ethical or Scientific Problem? ATLA 30, 219-227, 2002.

[v] وَلَا تَأْكُلُوا مِمَّا لَمْ يُذْكَرِ اسْمُ اللَّـهِ عَلَيْهِ وَإِنَّهُ لَفِسْقٌ (الأنعام 121)

إِنَّمَا حَرَّمَ عَلَيْكُمُ الْمَيْتَةَ وَالدَّمَ وَلَحْمَ الْخِنزِيرِ وَمَا أُهِلَّ بِهِ لِغَيْرِ اللَّـهِ (البقرة 173)

[vi] كنز الدقائق للنسفي، دار البشائر الإسلامية، ص 600

ولم يتذك جنين بذكاة أمه

مختصر القدوري في الفقه الحنفي، دار الكتب العلمية، ص 206

ومن نحر ناقة أو ذبح بقرة أو شاة فوجد في بطنها جنينا ميتا لم يؤكل أشعر أو لم يشعر

[vii] Morris, SJ et al. Laboratory-Scale Production of Replication-Deficient Adenovirus Vectored Vaccines.

“The MHRA can confirm that the COVID-19 Vaccine AstraZeneca does not contain any components of animal origin.”

https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca (Accessed Jan. 22, 2021)

[viii] شرح السير الكبير، شمس الأئمة السرخسي، الشركة الشرقية للإعلانات، ص 128

والآدمي محترم بعد موته على ما كان عليه في حياته. فكما يحرم التداوي بشيء من الآدمي الحي إكراما له فكذلك لا يجوز التداوي بعظم الميت. قال – صلى الله عليه وسلم -: «كسر عظم الميت ككسر عظم الحي»

الهداية في شرح بداية المبتدي، المرغيناني، ج 1، ص 23

” وشعر الإنسان وعظمه طاهر” وقال الشافعي نجس لأنه لا ينتفع به ولا يجوز بيعه ولنا أن عدم الإنتفاع والبيع لكرامته فلا يدل على نجاسته والله أعلم

البناية شرح الهداية، بدر الدين العينى، دار الكتب العلمية، ج 1، ص 105

أي لأجل كرامته؛ لأن الآدمي مكرم بالنص والضمير في به يرجع إلى الشعر، وفي كرامته يجوز أن يرجع إلى الشعر أيضا، ولكونه مكرما بكرامة صاحبه، ويجوز أن يرجع إلى الإنسان وهو الظاهر.

البحر الرائق شرح كنز الدقائق، ابن نجيم المصري، دار الكتاب الإسلامي، ج 1، ص 113

فإن المصرح به في البدائع والكافي وغيرهما بأن سن الآدمي طاهرة على ظاهر المذهب، وهو الصحيح وعلل له في البدائع بأنه لا دم فيها والمنجس هو الدم؛ ولأنه يستحيل أن تكون طاهرة من الكلب نجسة من الآدمي المكرم إلا أنه لا يجوز بيعها ويحرم الانتفاع بها احتراما للآدمي كما إذا طحن سن الآدمي مع الحنطة أو عظمه لا يباح تناول الخبز المتخذ من دقيقهما لا لكونه نجسا بل تعظيما له كي لا يصير متناولا من أجزاء الآدمي كذا هذا وكذا ذكر في المبسوط والنهاية والمعراج

فتاوى قاضيخان، فخر الدين حسن بن منصور الأوزجندي، ج 3، ص 247

مضطر لم يجد ميتة و خاف الهلاك فقال له رجل اقطع يدي و كلها أو قال اقطع مني قطعة فكلها لا يسعه أن يفعل ذلك ولا يصح أمره به كما لا يسع للمضطر أن يقطع قطعة من لحم نفسه فيأكل

الفتاوى الهندية، دار الفكر، ج 5، ص 354

وقال محمد – رحمه الله تعالى – ولا بأس بالتداوي بالعظم إذا كان عظم شاة أو بقرة أو بعير أو فرس أو غيره من الدواب إلا عظم الخنزير والآدمي فإنه يكره التداوي بهما فقد جوز التداوي بعظم ما سوى الخنزير والآدمي من الحيوانات مطلقا من غير فصل…

الانتفاع بأجزاء الآدمي لم يجز قيل للنجاسة وقيل للكرامة هو الصحيح كذا في جواهر الأخلاطي.

رد المحتار على الدر المختار، ابن عابدين، دار الفكر، ج 1، ص 204

في الدر: (وآدمي) فلا يدبغ لكرامته، ولو دبغ طهر وإن حرم استعماله، حتى لو طحن عظمه في دقيق لم يؤكل في الأصح احتراما.

في الرد: وأجيب بأن معنى طهر جاز استعماله والعلاقة السببية والمسببية لا اللزوم كما قيل، إذ لا يلزم من الطهارة جواز الانتفاع كما علمته، لكن علة عدم الانتفاع بهما مختلفة، ففي الخنزير لعدم الطهارة، وفي الآدمي لكرامته كما أشار إليه الشارح. قال في النهر: وهذا مع ما فيه من العدول عن المعنى الحقيقي أولى…
(قوله وإن حرم استعماله) أي استعمال جلده أو استعمال الآدمي بمعنى أجزائه وبه يظهر التفريع بعده (قوله احتراما) أي لا نجاسة (قوله وأفاد كلامه) حيث لم يستثن من مطلق الإهاب سوى الخنزير والآدمي

كتاب النوازل، مفتي سيد محمد منصوربوري، المركز العلمي، ج 16، ص 209

چند اهم عصری مسائل، زين الاسلام قاسمي، مكتبة دار العلوم ديوبند، ج 2، ص 335-336

[ix] رد المحتار على الدر المختار، ابن عابدين، دار الفكر، ج 1، ص 207

في الدر: (وشعر الإنسان) غير المنتوف (وعظمه) وسنه مطلقا على المذهب. واختلف في أذنه، ففي البدائع نجسة، وفي الخانية لا، وفي الأشباه: المنفصل من الحي كميتته إلا في حق صاحبه فطاهر وإن كثر. ويفسد الماء بوقوع قدر الظفر من جلده لا بالظفر

في الرد: أقول: وعليه فما يبقى بين أسنان المشط ينجس الماء القليل إذا بل فيه وقت التسريح، لكن يؤخذ من المسألة الآتية كما قال ط أن ما خرج من الجلد مع الشعر إن لم يبلغ مقدار الظفر لا يفسد الماء تأمل (قوله مطلقا) أي سواء كان سنه أو سن غيره من حي أو ميت قدر الدرهم أو أكثر حمله معه أو أثبته مكانه كما يعلم من الحلية والبحر (قوله على المذهب) قال في البحر: المصرح به في البدائع والكافي وغيرهما أن سن الآدمي طاهرة على ظاهر المذهب وهو الصحيح؛ لأنه لا دم فيها، والمنجس هو الدم بدائع وما في الذخيرة وغيرها من أنها نجسة ضعيف. اهـ (قوله ففي البدائع نجسة) فإنه قال: ما أبين من الحي إن كان جزءا فيه دم كاليد والأذن والأنف ونحوها فهو نجس بالإجماع، وإلا كالشعر والظفر فطاهر عندنا. اهـ ملخصا (قوله وفي الخانية لا) حيث قال: صلى وأذنه في كمه أو أعادها إلى مكانها تجوز صلاته في ظاهر الرواية. اهـ ملخصا. وعلله في التجنيس بأن ما ليس بلحم لا يحله الموت فلا يتنجس بالموت أي والقطع في حكم الموت. واستشكله في البحر بما مر عن البدائع. وقال في الحلية: لا شك أنها مما تحلها الحياة ولا تعرى عن اللحم، فلذا أخذ الفقيه أبو الليث بالنجاسة وأقره جماعة من المتأخرين. اهـ. وفي شرح المقدسي قلت: والجواب عن الإشكال أن إعادة الأذن وثباتها إنما يكون غالبا بعود الحياة إليها فلا يصدق أنها مما أبين من الحي؛ لأنها بعود الحياة إليها صارت كأنها لم تبن، ولو فرضنا شخصا مات ثم أعيدت حياته معجزة أو كرامة لعاد طاهرا. اهـ.

الهداية في شرح بداية المبتدي، المرغيناني، دار احياء التراث العربي، ج 1، ص 25

قال: “وإن ماتت فيها شاة أو كلب أو آدمي نزح جميع ما فيها من الماء” لأن ابن عباس وابن الزبير رضي الله عنهما أفتيا بنزح الماء كله حين مات زنجي في بئر زمزم

البحر الرائق شرح كنز الدقائق، ابن نجيم المصري، ج 1، ص 113

وقيل هو عظم وما وقع في الذخيرة وغيرها من أن أسنان الكلب إذا كانت يابسة طاهرة وأسنان الآدمي نجسة بناء على أن الكلب يطهر بالذكاة وما يطهر بها فعظمه طاهر بخلاف الآدمي فضعيف، فإن المصرح به في البدائع والكافي وغيرهما بأن سن الآدمي طاهرة على ظاهر المذهب، وهو الصحيح وعلل له في البدائع بأنه لا دم فيها والمنجس هو الدم؛ ولأنه يستحيل أن تكون طاهرة من الكلب نجسة من الآدمي المكرم…

لكن ما ذكره في السن مسلم أما الأذن فقد قال في البدائع ما أبين من الحي من الأجزاء إن كان المبان جزءا فيه دم كاليد والأذن والأنف ونحوها، فهو نجس بالإجماع، وإن لم يكن فيه دم كالشعر والصوف والظفر، فهو طاهر عندنا خلافا للشافعي اهـ….

وفي الخلاصة وفتاوى قاضي خان والتجنيس والمحيط جلد الإنسان إذا وقع في الماء أو قشره إن كان قليلا مثل ما يتناثر من شقوق الرجل ونحوه لا يفسد الماء، وإن كان كثيرا يعني قدر الظفر يفسد والظفر لا يفسد الماء اهـ. وعلل له في التجنيس بأن الجلد والقشر من جملة لحم الآدمي والظفر عصب، وهذا كله مذهبنا

[x]  مصنوعى گوشت کے حوالے سے چند استفادات، دار الإفتاء جامعة الرشيدية، #63210\57.

[xi] القواعد الفقهية وتطبيقاتها في المذاهب الأربعة، محمد مصطفى الزحيلي، ج 1، ص 129-134


المجموعة للقواعد الفقهية، مفتي عميم الإحسان، البشرى، ص 43.

الأشباه والنظائر لابن نجيم، دار الكتب العلمية، ص 49

مُوْسُوعَة القَواعِدُ الفِقْهِيَّة، ج 9، ص 486

المتولّد من الأصل يكون بصفة الأصل

فما تولّد من أصل فهو فرع له، والفرع يأخذ صفة أصله وحكمه من الحل أو الحرمة أو الجواز وعدمه أو الملك وعدمه.

[xii] الهداية في شرح بداية المبتدي للمرغيناني، دار احياء التراث العربي، ج 1، ص 18

والدابة تخرج من الدبر ناقضة فإن خرجت من رأس الجرح أو سقط اللحم لا تنقض والمراد بالدابة الدودة وهذا لأن النجس ما عليها وذلك قليل وهو حدث في السبيلين دون غيرهما

فتح القدير، بابن الهمام، دار الفكر، ج 1، ص 53

(قوله لأن النجس ما عليها) المعنى؛ لأن ما بحيث يكون نجسا هو ما عليها

البناية شرح الهداية، بدر الدين العينى، دار الكتب العلمية، ج 1، ص 306

لأن النقض بالخروج لا بنفس الدابة فافهم.

العناية شرح الهداية، جمال الدين الرومي البابرتي، دار الفكر، ج 1، ص 52

لأن نفس الدودة ليست بنجسة، ولهذا لو غسلت جازت الصلاة معها فلم يبق من النجس إلا ما عليها

درر الحكام شرح غرر الأحكام، ملا خسرو، دار إحياء الكتب العربية، ج 1، ص 13

(و) خروج (ريح أو دودة أو حصاة من الدبر) ذكر الريح لأنه خارج منه وليس بنجس مع أنه ناقض لمجاورة النجس وذكر الآخرين لأن ما معهما من النجس وإن قل حدث في السبيلين

مجمع الأنهر في شرح ملتقى الأبحر، عبد الرحمن بن محمد بن سليمان المدعو بشيخي زاده، دار إحياء التراث العربي، ج 1، ص 21

(ولا خروج دودة من جرح) وكذا من أذن أو أنف؛ لأنها متولدة من لحم طاهر وما عليها قليل، والقليل غير ناقض في غير السبيلين.

رد المحتار على الدر المختار، ابن عابدين، دار الفكر، ج 1، ص 184

في الدر: وفي الوهبانية دود القز وماؤه وبزره وخرؤه طاهر كدودة متولدة من نجاسة

في الرد: (قوله: كدودة إلخ) فإنها طاهرة ولو خرجت من الدبر، والنقض إنما هو لما عليها لا لذاتها ط وقدمنا قولا بنجاستها، وعلى الأول فإذا وقعت في الماء لا ينجس لكن لو بعد غسلها كما قيد في البزازية فما في القنية من أنه ينجس محمول على ما قبل الغسل.

عمدة الرعاية بتحشية شرح الوقاية، الإمام محمد عبد الحي اللكنوي، مركز العلماء العالمي للدراسات وتقنية المعلومات، ج 1، ص 345

قوله: لأنها طاهرة؛ أشار بذلك إلى وجهين للفرق بين دودة الجرح وبين دودة الدبر، الأول: إن الدودة حيوان طاهر في الأصل وإن كان أصله من النجس، والطاهر إذا خرج من أحد السبيلين نقض الوضوء كالريح، بخلاف غيرهما، فإن الخارج الطاهر منه لا ينقض، كالدمع والعرق، والثاني: إن الدودة لا تخلو عن قليل نجاسة، وقليل النجاسة إذا خرجت من أحد السبيلين نقض الوضوء، ومن غيرهما لا ينقض إلا إذا كان كثيرا.

الهدية العلائية، محمد علاء الدين بن محمد أمين عابدين، دار ابن حزم، ص 40

يصح رفع الحدث بما ذُكر من أقسام الماء المطلق، وان مات فيه، ولو قليلا… دودة ولو موتولِّدة من نجاسة أو خارجة من دبر بعد غسلها.

الكتاب : الفتاوى البزازية، ج 1، ص 9

الدودة المتولدة من النجاسة طاهرة حتى إذا وقعت في الماء بعد غسلها لا ينجس وكذا دودة كل حيوان ويجوز الصلاة معها

[xiii] وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ (الأعراف 157)

 بدائع الصنائع في ترتيب الشرائع، علاء الدين الكاساني، دار الكتب العلمية، ج 5، ص 36

(وأما) الذي يعيش في البر فأنواع ثلاثة: ما ليس له دم أصلا، وما ليس له دم سائل، وما له دم سائل مثل الجراد والزنبور والذباب والعنكبوت والعضابة والخنفساء والبغاثة والعقرب. ونحوها لا يحل أكله إلا الجراد خاصة؛ لأنها من الخبائث لاستبعاد الطباع السليمة إياها وقد قال الله تبارك وتعالى {ويحرم عليهم الخبائث} [الأعراف: 157] إلا أن الجراد خص من هذه الجملة بقوله – عليه الصلاة والسلام – «أحلت لنا ميتتان» فبقي على ظاهر العموم. وكذلك ما ليس له دم سائل مثل الحية والوزغ وسام أبرص وجميع الحشرات وهوام الأرض من الفأر والقراد والقنافذ والضب واليربوع وابن عرس ونحوها، ولا خلاف في حرمة هذه الأشياء إلا في الضب

[xiv] “This medicine contains a very small amount of alcohol (0.002 g of alcohol (ethanol) per dose of 0.5 ml). This is not enough to cause any noticeable effects.”

https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca (Accessed Jan 22, 2021)

[xv] تكملة فتح الملهم، مفتي تقي عثماني، دار إحياء التراث العربي، ج 3، ص 506

وبهذا يتبين حكم الكحول المسكرة (AL COHALS) التي عمت بها البلوى اليوم، فإنها تستعمل في كثير من الأدوية والعطور والمركبات الأخرى، فإنها إن اتخذت من العنب أو التمر فلا سبيل إلى حلتها أو طهارتها، وإن اتخذت من غيرهما فالأمر فيها سهل على مذهب أبي حنيفة رحمة لله تعالى، ولا يحرم استعمالها للتداوي أو لأغراض مباحة أخرى ما لم تبلغ حد الإسكار، لأنها إنما تستعمل مركبة مع المواد الأخرى، ولا يحكم بنجاستها أخذا بقول أبي حنيفة رحمة لله.

أحسن الفتاوى، مفتي رشيد اللديانوي، ج 8، ص 488-490

Islamically Permissible COVID-19 Vaccines: mRNA Page

Prepared by Mawlana Mateen A. Khan MD, Dr. Ramzan Judge PharmD, Dr. Samad Tirmizi PharmD, and Mufti Adil Farooki MD.

Summary:

Pfizer-BioNtech and Moderna COVID-19 vaccines are ḥalāl and permissible to take.

Summary page for all assessed COVID-19 vaccines

Discussion:

The first class of vaccine to come to market in the United States are mRNA vaccines developed by BioNTech/ Pfizer and Moderna. mRNA vaccines are novel vaccines encapsulating genetic material in lipid nanoparticles. It is thought these particles fuse with the cell membrane of a eukaryote to deliver the mRNA into its cytoplasm. Here, it is translated into the active antigen. Unlike previous vaccines, production of mRNA vaccines do not employ any cell lines or growth medium.[i]

Figure 1: Drawing of a lipid nanoparticle

Pfizer-BioNtech & Moderna COVID Vaccines

The vaccines developed by Pfizer/ BioNTech and Moderna are mRNA vaccines named BNT162b2 and mRNA-1273 respectively. [ii] The mRNA encodes for the receptor binding domain of the virus’s S1 protein. It is entirely synthetic. There are nine other ingredients (Table 1[iii]). Ingredients 2-5 of each vaccine make up the lipid nanoparticle. Although, these components can be sourced from plant or animal sources, we have assurances from the manufacturers and government agencies that the vaccines do not contain any components of animal origin. [iv] The rest of its components are excipients[v] of ḥalāl origin. Therefore, all ingredients of the Pfizer/BioNTech and Moderna COVID vaccines are ḥalāl, being either non-animal derived synthetic components or excipients.


[i] Annette B. Vogel, Isis Kanevsky et al. A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates. BioRxiv, September 08, 2020. https://doi.org/10.1101/2020.09.08.280818

Corbett, K.S., Edwards, D.K., Leist, S.R. et al. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature 586, 567–571 (2020). https://doi.org/10.1038/s41586-020-2622-0

[ii] For a better general understanding of Pfizer-BioNTech’s vaccine, see: https://biontech.de/covid-19

[iii] https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html. Accessed December 24, 2020.

[iv] “The Medicines and Healthcare products Agency can confirm that the Pfizer/BioNTech COVID-19 vaccine does not contain any components of animal origin.”

https://www.gov.uk/government/publications/regulatory-approval-of-pfizer-biontech-vaccine-for-covid-19. Accessed 12/5/2020. Confirmation via email correspondence with MHRA on December 17, 2020.

The vaccine provided in the UK is identical in composition to what is provided in the US. (Verbal confirmation from Pfizer representative on December 4, 2020.)

“Our vaccine is free of animal ingredients. The production of it is synthetic.” (Email correspondence from BioNTech. December 7, 2020.)

Moderna vaccine does not contain animal derivatives. (Verbal confirmations from Moderna MSL(s) on December 23 & 24, 2020.)

“Moderna COVID-19 Vaccine does not contain any preservatives, antibiotics, adjuvants, or human- or animal-derived materials.” (Official written statement from Moderna dated December 27, 2020. Also: https://covid-vaccine.canada.ca/info/pdf/moderna-covid-19-vaccine-pm1.pdf. Accessed December 28, 2020).

[v] The excipients as listed in Table 1 include salts, buffers, and sugar. The Pfizer/BioNtech vaccine contains four salts including table salt. Moderna vaccine uses tromethamine, an ingredient found in commonly used medications. These ingredients are primarily used to balance pH. Additionally, Moderna vaccine includes acetic acid, the main component of vinegar, and its salt.

Islamically Permissible COVID-19 Vaccines: Summary Page

Prepared by Mawlana Mateen A. Khan MD, Dr. Ramzan Judge PharmD, Dr. Samad Tirmizi PharmD, and Mufti Adil Farooki MD.

Summary:

Pfizer-BioNtech and Moderna COVID-19 vaccines are ḥalāl and permissible to take.

Oxford-AstraZeneca and Janssen (Johnson & Johnson) COVID-19 vaccines are ḥalāl and permissible for use although other vaccines without ethical issues (e.g., mRNA vaccines) are preferable when available.

(See links below for more detailed explanations. Other vaccines have not been evaluated yet due to lack of information and/or vaccine unavailability in the US.)

Introduction:

In December 2019, the World Health Organization was alerted to an outbreak which would eventually be identified as SARS-CoV-2 or COVID-19. Caused by a betacoronavirus, COVID-19 most often effects the lower respiratory tract. The virus binds to angiotensin converting enzyme 2 (ACE2) receptor, which is found in almost all organs of the body especially the lungs, brain, and gut. Therefore, the virus has the potential to affect most of the body. On March 11, 2020, the WHO officially declared it a pandemic as it quickly spread across the globe. As of February 2, 2021, there are over 103 million worldwide cases and over 2.2 million deaths have been attributed to it.[i] In an unprecedented move, countries across the world embarked on an effort to quickly develop drugs and vaccines. Linked below are articles which discuss the vaccines currently available or soon to be available in the United States including the permissibility or impermissibility of their ingredients in the Sharī`ah. It makes no assessment of the vaccines’ medical benefit or lack thereof. One should consult a qualified and trusted medical personnel to better assess personal benefit.

More Detailed Discussions:

mRNA Vaccine Page

Viral Vector Vaccine Page


[i] COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) https://coronavirus.jhu.edu/map.html. Accessed 02/02/2021.

Islamically Permissible Influenza Vaccines Available in the US for 2020-2021 Season

Prepared by Mawlana Dr. Mateen A. Khan, MD and Dr. Ramzan Judge, PharmD

Summary

Permissible influenza vaccines in the US for 2020-2021 season

  • FluadTM Trivalent
  • FluadTM Quadrivalent
  • Fluzone High-DoseTM Quadrivalent
  • AfluriaTM
  • FluarixTM
  • FluLavalTM
  • FluzoneTM Quadrivalent

Impermissible influenza vaccines in the US for 2020-2021 season

  • FlublokTM
  • FluMistTM
  • FlucelvaxTM

Discussion

Background on Influenza

Influenza (commonly known as the flu) is a seasonal viral illness carrying significant health, economic, and social burden. For the past nine years, the Centers for Disease Control and Prevention (CDC) estimates that every year 9.3-49 million symptomatic illnesses, 4.3-23 million medical visits, 140,000-960,000 hospitalizations, and 12,000-79,000 deaths are attributed to seasonal influenza. For the 2017-2018 season, which was considered high severity, a study estimated influenza vaccination prevented:

  • 7.1 million illnesses
  • 3.7 million medical visits
  • 109,000 hospitalizations (10% of expected overall and 41% among young children)
  • 8,000 deaths[i]

In addition to providing immunity to healthy individuals, the vaccine benefits the sick by decreasing the amount of exposure from other individuals (herd immunity). Hence, the CDC, along with most American medical organizations, recommends that every person above six months old receive a seasonal influenza vaccine yearly.[ii]

Improving vaccination rates among Muslims has been a struggle. Muslim majority countries find their populations hesitant. [iii] Similar issues are faced among Muslim minority populations in the West over a concern for the presence of impermissible ingredients in the vaccine.[iv]

The United States currently offers nine different commercially prepared vaccines. We reviewed package inserts and public records for the vaccines to evaluate methods of production and the presence of impermissible products. When necessary, we corresponded with the manufacturers. The results are compiled in Table 1. The vaccines vary in their methods of production and ingredients, which may pose religious challenges for Muslims.

Issue #1 – Methods of Production

Influenza vaccines are prepared through three different processes. Most strains are prepared through an egg-based manufacturing process. This involves injecting vaccine viruses into fertilized chicken eggs. Essentially, the egg is commandeered as a factory by the viruses as they use the egg’s resources to replicate themselves. The viruses are extracted and purified.[v] Islamically, this process per se is not an issue as eggs are considered permissible.

Flucelvax™, a product by Seqirus, is made by incubating influenza viruses in a particular animal cell line, Madin-Darby Canine Kidney (MDCK).[vi] The MDCK cell line was initially isolated in 1958 from an adult Cocker Spaniel dog.[vii] Dogs, like all predators, are ḥarām as Sayyidunā Ibn `Abbās (May Allah be pleased with him) narrated that Allah’s Messenger ﷺ prohibited every predator possessing canine teeth.[viii] Further, when cells like MDCK are removed from an animal, they are considered maytah (carrion) in Islamic terminology. The Prophet ﷺ informed us, “Whatever is cut from an animal while it is alive is carrion.”[ix] Surah al-An`ām states a ruling of najis and arām for carrion.

“Say, “I do not find, in what has been revealed to me, anything prohibited for anyone who eats it, unless it be carrion or blood that pours forth, or flesh of swine – because it is impure.”[x]

Hence, the initially harvested canine cells were najis and ḥarām. Since 1958, the cell line has undergone countless replication cycles in artificial environments, and the parent cells have long died off. Still, being the progeny cells, they will be impure and impermissible.

The MDCK cells used in Flucelvax™ are grown in a medium in which no human or animal-derived materials are used.[xi] After an incubation period, the cells are processed through lysis, and the virus proteins undergo extraction and purification. Despite this, residual amounts of the cells capable of inducing allergic reaction in susceptible patients remain, per the package insert. For these reasons, Flucelvax™ vaccine made from this method is impermissible.

FlublokTM manufactured by Sanofi, is produced by genetically engineering proteins expressed by influenza into an alternate virus, baculovirus (Autographa californica). It is then used to infect an insect cell line (ExpresSF+) derived from the fall armyworm (Spodoptera frugiperda), which produces the desired influenza proteins. This vaccine is especially valuable to those who have severe allergies to eggs. [xii] Insects, like the armyworm, fall into the category of al-khabā’ith explicitly mentioned in the Qur’an as arām in Surah al-A`rāf.

[He ﷺ] makes unlawful for them impure things (al-khabā’ith).[xiii]

Similar to animal cell lines discussed previously, the progeny ExpresSF+ cells are impure and impermissible. Hence, FlublokTM vaccine made from this method is also impermissible.

Issue #2 – Porcine Gelatin as a Stabilizer

Two of the vaccines available in the United States, FluMistTM and Flucelvax™, contain porcine gelatin. The gelatin is added as a stabilizer for the viral vaccine protein. Gelatin is hydrolyzed collagen, which is extracted from collagen-containing tissue like skin and bones. At the outset, the Qur’an declares that all porcine parts are najis and ḥarām.

Say, “I do not find, in what has been revealed to me, anything (out of the cattle under discussion) prohibited for anyone who eats it, unless it be carrion or blood that pours forth, or flesh of swine – because it is impure – or there be an animal slaughtered sinfully by invoking on it the name of someone other than Allah. (Surah al-An`ām:145)[xiv]

He has but prohibited for you the carrion, the blood, the flesh of swine and what has been invoked upon with a name other than that of Allah. (Surah al-Naḥl:115)[xv]

In earlier times, gelatin was prepared in homes through a process of cooking, causing the collagen to hydrolyze and break into peptides of varying lengths. Although the process today is commercialized and done through a series of chemical reactions, extraction, and purification, the result is not much different from home preparations. These peptides do not constitute a significant change from the original porcine collagen. Instead, gelatin is just fragmented hydrolyzed collagen. The resulting gelatin is impermissible.[xvi] Hence, FluMistTM and Flucelvax™ are impermissible particularly when other permissible alternatives exist.

Exceptional Cases

If someone is unable to take or obtain one of the permissible influenza vaccines, and they are relatively healthy, they should not take an impermissible vaccine.[xvii] However, if a strong need exists, then they may take those vaccines that are normally impermissible. An example of a strong medical need is when there is a high likelihood (ghalabah al-ann) of significant morbidity or mortality in contracting influenza such as in the very old or patients with pre-existing significant comorbidities. Ideally, the Sharī`ah prefers a competent Muslim physician to determine this need based upon the evidences at hand. The physician should be pious and have a basic understanding of the relevant Sharī`ah rulings.[xviii] Vaccinations mandated by the government, work places, or schools may also constitute a strong need.[xix] In any of these situations, one may take (in order of preference) FlublokTM, FluMistTM, and FlucelvaxTM.

Conclusion

Of the ten commercially available influenza vaccines available in the US for the 2020-2021 season, seven are Islamically permissible: FluadTM Trivalent, FluadTM Quadrivalent, Fluzone High-DoseTM, AfluriaTM, FluarixTM, FluLavalTM, and FluzoneTM Quadrivalent. The Muslim public is advised to avoid FlublokTM, FluMistTM, and FlucelvaxTM.

In exceptional cases, as outlined above, one may take FlublokTM, FluMistTM, and FlucelvaxTM in that order.

Of note, vaccine formulations are subject to change year to year. The research presented here is accurate for the 2020-2021 season.

Table 1: 2020-2021 Influenza Vaccines


[i] Rolfes, M.A. (2019). Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season. Clinical Infectious Diseases, ciz075, doi.org/10.1093/cid/ciz075.

[ii] https://www.cdc.gov/flu/prevent/whoshouldvax.htm.

[iii] Ahmed, A. (2018) Outbreak of vaccine-preventable diseases in Muslim majority countries. Journal of Infection and Public Health, 11 (2), 153-155. doi.org/10.1016/j.jiph.2017.09.007

[iv] https://mcb.org.uk/mcb-updates/position-on-flu-vaccines/.

[v] https://www.cdc.gov/flu/prevent/how-fluvaccine-made.htm#targetText=The%20most%20common%20way%20that,for%20more%20than%2070%20years.&targetText=For%20flu%20shots%2C%20the%20influenza,and%20virus%20antigen%20is%20purified.

[vi] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177469/

[vii] https://en.wikipedia.org/wiki/Madin-Darby_Canine_Kidney_cells#targetText=Madin%2DDarby%20Canine%20Kidney%20(MDCK,as%20responses%20to%20growth%20factors.

[viii] عَنِ ابْنِ عَبَّاسٍ، قَالَ نَهَى رَسُولُ اللَّهِ صلى الله عليه وسلم عَنْ كُلِّ ذِي نَابٍ مِنَ السِّبَاعِ (مسلم 1934)

[ix] مَا قُطِعَ مِنَ الْبَهِيمَةِ وَهِيَ حَيَّةٌ فَهِيَ مَيْتَةٌ (أبو داوود 2858، الترمذي 1480، ابن ماجه 3216)

وَعَلَى هَذَا يَخْرُجُ مَا إذَا قَطَعَ مِنْ أَلْيَةِ الشَّاةِ قِطْعَةً أَوْ مِنْ فَخِذِهَا أَنَّهُ لَا يَحِلُّ الْمُبَانُ وَإِنْ ذُبِحَتْ الشَّاةُ بَعْدَ ذَلِكَ؛ لِأَنَّ حُكْمَ الذَّكَاةِ لَمْ يَثْبُتْ فِي الْجُزْءِ الْمُبَانِ وَقْتَ الْإِبَانَةِ لِانْعِدَامِ ذَكَاةِ الشَّاةِ لِكَوْنِهَا حَيَّةً وَقْتَ الْإِبَانَةِ، وَحَالَ فَوَاتِ الْحَيَاةِ كَانَ الْجُزْءُ مُنْفَصِلًا وَحُكْمُ الذَّكَاةِ لَا يَظْهَرُ فِي الْجُزْءِ الْمُنْفَصِلِ وَرُوِيَ أَنَّ أَهْلَ الْجَاهِلِيَّةِ كَانُوا يَقْطَعُونَ قِطْعَةً مِنْ أَلْيَةِ الشَّاةِ وَمِنْ سَنَامِ الْبَعِيرِ فَيَأْكُلُونَهَا فَلَمَّا بُعِثَ النَّبِيُّ الْمُكَرَّمُ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – نَهَاهُمْ عَنْ ذَلِكَ فَقَالَ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «مَا أُبِينَ مِنْ الْحَيِّ فَهُوَ مَيِّتٌ» وَالْجُزْءُ الْمَقْطُوعُ مُبَانٌ مِنْ حَيٍّ وَبَائِنٌ مِنْهُ فَيَكُونُ مَيِّتًا وَكَذَلِكَ إذَا قُطِعَ ذَلِكَ مِنْ صَيْدٍ لَمْ يُؤْكَلْ الْمَقْطُوعُ، وَإِنْ مَاتَ الصَّيْدُ بَعْدَ ذَلِكَ لِمَا قُلْنَا. (بدائع الصنائع في ترتيب الشرائع)

[x] قُل لَّا أَجِدُ فِي مَا أُوحِيَ إِلَيَّ مُحَرَّمًا عَلَىٰ طَاعِمٍ يَطْعَمُهُ إِلَّا أَن يَكُونَ مَيْتَةً أَوْ دَمًا مَّسْفُوحًا أَوْ لَحْمَ خِنزِيرٍ فَإِنَّهُ رِجْسٌ أَوْ فِسْقًا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

[xi] European Medicines Agency Assessment Report on Flucelvax Tetra. 18 Oct. 2018. Pg. 14.

[xii] Barr, I. G. (2018). Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness. NPJ vaccines, 3, 44. doi:10.1038/s41541-018-0079-z

See also https://www.cdc.gov/flu/prevent/egg-allergies.htm for discussion on egg allergies and influenza vaccines.

[xiii] وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ

(وَأَمَّا) الَّذِي يَعِيشُ فِي الْبَرِّ فَأَنْوَاعٌ ثَلَاثَةٌ: مَا لَيْسَ لَهُ دَمٌ أَصْلًا، وَمَا لَيْسَ لَهُ دَمٌ سَائِلٌ، وَمَا لَهُ دَمٌ سَائِلٌ مِثْلُ الْجَرَادِ وَالزُّنْبُورِ وَالذُّبَابِ وَالْعَنْكَبُوتِ وَالْعَضَّابَةِ وَالْخُنْفُسَاءِ وَالْبُغَاثَةِ وَالْعَقْرَبِ.

وَنَحْوِهَا لَا يَحِلُّ أَكْلُهُ إلَّا الْجَرَادَ خَاصَّةً؛ لِأَنَّهَا مِنْ الْخَبَائِثِ لِاسْتِبْعَادِ الطِّبَاعِ السَّلِيمَةِ إيَّاهَا وَقَدْ قَالَ اللَّهُ تَبَارَكَ وَتَعَالَى {وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ} [الأعراف: 157] إلَّا أَنَّ الْجَرَادَ خُصَّ مِنْ هَذِهِ الْجُمْلَةِ بِقَوْلِهِ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «أُحِلَّتْ لَنَا مَيْتَتَانِ» فَبَقِيَ عَلَى ظَاهِرِ الْعُمُومِ. وَكَذَلِكَ مَا لَيْسَ لَهُ دَمٌ سَائِلٌ مِثْلُ الْحَيَّةِ وَالْوَزَغِ وَسَامِّ أَبْرَصَ وَجَمِيعِ الْحَشَرَاتِ وَهَوَامِّ الْأَرْضِ مِنْ الْفَأْرِ وَالْقُرَادِ وَالْقَنَافِذِ وَالضَّبِّ وَالْيَرْبُوعِ وَابْنِ عِرْسٍ وَنَحْوِهَا، وَلَا خِلَافَ فِي حُرْمَةِ هَذِهِ الْأَشْيَاءِ إلَّا فِي الضَّبِّ (بدائع الصنائع في ترتيب الشرائع)

[xiv] قُل لَّا أَجِدُ فِي مَا أُوحِيَ إِلَيَّ مُحَرَّمًا عَلَىٰ طَاعِمٍ يَطْعَمُهُ إِلَّا أَن يَكُونَ مَيْتَةً أَوْ دَمًا مَّسْفُوحًا أَوْ لَحْمَ خِنزِيرٍ فَإِنَّهُ رِجْسٌ أَوْ فِسْقًا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

[xv] إِنَّمَا حَرَّمَ عَلَيْكُمُ الْمَيْتَةَ وَالدَّمَ وَلَحْمَ الْخِنزِيرِ وَمَا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

[xvi] Respectfully, the minority opinion considering gelatin to have undergone a significant transformation (tabdīl al-mahiyah) rendering its ruling changed seems doubtful for the reasons outlined. This is an extensive discussion. However, with the availability of clearly ḥalāl alternatives, the opinion given in this article is more cautious.

[xvii] The authors are currently unaware of any clinical scenario in which an Islamically permissible vaccine is contraindicated. The CDC recommends egg cultured vaccines even in patients with prior anaphylactic reactions to eggs. (See: https://www.cdc.gov/flu/prevent/egg-allergies.htm) This statement is included as a hypothetical clinical scenario.

[xviii] وَجَوَّزَهُ فِي النِّهَايَةِ بِمُحَرَّمٍ إذَا أَخْبَرَهُ طَبِيبٌ مُسْلِمٌ أَنَّ فِيهِ شِفَاءً وَلَمْ يَجِدْ مُبَاحًا يَقُومُ مَقَامَهُ. قُلْت: وَفِي الْبَزَّازِيَّةِ وَمَعْنَى قَوْلِهِ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «إنَّ اللَّهَ لَمْ يَجْعَلْ شِفَاءَكُمْ فِيمَا حُرِّمَ عَلَيْكُمْ» نَفْيُ الْحُرْمَةِ عِنْدَ الْعِلْمِ بِالشِّفَاءِ دَلَّ عَلَيْهِ جَوَازُ شُرْبِهِ لِإِزَالَةِ الْعَطَشِ (رد المحتار على الدر المختار)

[xix] Imdād al-Fatāwa Jadīd ma`a Hāshiyah Shabbīr Aḥmad al-Qāsimī, 9:262

Use of Orally Dissolving and Sublingual Medications While Fasting

Question: Do orally dissolving or sublingual medications like ondansetron and lorazepam break the fast? 

Answer:

Bismihi Ta’ala

Orally dissolving tablets (ODT) and sublingual (SL) routes allow for mucosal absorption of medications. This is particularly beneficial in patients with difficulty swallowing (dysphagia). It also bypasses gastric and enteral breakdown and liver first-pass metabolism. The medication must first be diluted into saliva before absorption into the mucosa. The patient must avoid eating, drinking, smoking, and possibly talking to keep the tablet in place to dissolve and give time to transfer from the saliva into the mucosa. This time is variable depending on drug and patient characteristics. 

In the case of ondansetron ODT and lorazepam SL, bioavailability is about 56% and 94% respectively indicating some portion of the drug remains in the saliva. This is likely the case even more so for the delivery (filling) agents. This is also reflected in the package insert administration instructions: 

  • Ondansetron ODT: “Immediately place the Zofran ODT tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva.” 
  • Lorazepam SL: “The sublingual tablet, when placed under the tongue, will dissolve in approximately 20 seconds. The patients should not swallow for at least 2 minutes to allow sufficient time for absorption.” 

If the package insert is followed for Ondansetron ODT and the medication is swallowed, the fast is broken, and it will need to be repeated (qaā). If there was a medical necessity for taking it, there is no penalty (kaffārah). Otherwise, there is a penalty. 

If the package insert is followed for lorazepam SL, it presents us with two scenarios: 

  1. The drug is not necessary while fasting. Taking the medication is impermissible (makrūh taḥrīmī) because the chances of it entering the posterior pharynx is high and thus, unnecessarily risks one’s fast. If one were to take it, one would incur the sin. Additionally, if any portion of saliva or drug is swallowed unintentionally, the fast breaks, and it will need to be repeated (qaḍā’) without a penalty (kaffārah). If it is swallowed intentionally, then a penalty would also be due. 
     
  2. The drug is necessary. Taking the medication via the orally dissolving or sublingual route is permissible. The saliva should not be swallowed, and any traces of the drug should be washed out of the mouth. If any portion of saliva or drug is swallowed either intentionally or unintentionally, the fast breaks, and it will need to be repeated (qaḍā’) without a penalty (kaffārah).

And Allah knows best

Shaykh Mateen Khan, MD

Mufti Adil Farooki, MD

Dr Ramzan Judge, PharmD

Dr Samad Tirmizi, Pharm D

References

Sublingual route for systemic drug delivery, https://doi.org/10.22270/jddt.v8i6-s.2097 

Orally Disintegrating Tablets: A Review, https://doi.org/10.4314/tjpr.v8i2.44525 

Pharmacokinetic Comparison of Sublingual Lorazepam with Intravenous, Intramuscular, and Oral Lorazepam, https://doi.org/10.1002/jps.2600710227 

Efficacy of orally disintegrating ondansetron in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy, https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2044.2008.05860.x 

حاشية الطحطاوي على مراقي الفلاح شرح نور الإيضاح، دار الكتب العلمية بيروت، 679 

قوله: “لما فيه من تعريض الصوم للفساد” لأن الجاذبة قوية فلا يؤمن أن تجذب منه شيئا إلى الباطن عناية 

الفتاوى الهندية، دار الفكر، 1:199 

وَكُرِهَ ذَوْقُ شَيْءٍ، وَمَضْغُهُ بِلَا عُذْرٍ كَذَا فِي الْكَنْزِ. وَمِنْ الْعُذْرِ فِي الْأَوَّلِ مَا لَوْ كَانَ زَوْجُ الْمَرْأَةِ وَسَيِّدُهَا سَيِّئَ الْخُلُقِ فَذَاقَتْ الْمَرَقَةَ، وَمِنْ الْعُذْرِ فِي الثَّانِي أَنْ لَا تَجِدَ مَنْ يَمْضُغُ الطَّعَامَ لِصَبِيِّهَا مِنْ حَائِضٍ أَوْ نُفَسَاءَ أَوْ غَيْرِهِمَا مِمَّنْ لَا يَصُومُ، وَلَمْ تَجِدْ طَبِيخًا، وَلَا لَبَنًا حَلِيبًا كَذَا فِي النَّهْرِ الْفَائِقِ وَذَكَرَ فِي التَّجْنِيسِ أَنَّ كَرَاهَةَ الذَّوْقِ فِي صَوْمِ الْفَرْضِ، وَأَمَّا التَّطَوُّعُ فَلَا بَأْسَ كَذَا فِي النِّهَايَةِ. وَيُكْرَهُ لِلصَّائِمِ أَنْ يَذُوقَ الْعَسَلَ أَوْ الدُّهْنَ لِيَعْرِفَ الْجَيِّدَ مِنْ الرَّدِيءِ عِنْدَ الشِّرَاءِ كَذَا فِي فَتَاوَى قَاضِي خَانْ. وَقِيلَ لَا بَأْسَ بِهِ إذَا لَمْ يَجِدْ بُدًّا مِنْ شِرَائِهِ أَوْ يَخَافُ الْغَبْنَ كَذَا فِي الزَّاهِدِيِّ. 

الفتاوى الهندية، دار الفكر، 1:202 

لَوْ أَكَلَ مُكْرَهًا أَوْ مُخْطِئًا عَلَيْهِ الْقَضَاءُ دُونَ الْكَفَّارَةِ كَذَا فِي فَتَاوَى قَاضِي خَانْ. الْمُخْطِئُ هُوَ الذَّاكِرُ لِلصَّوْمِ غَيْرُ الْقَاصِدِ لِلْفِطْرِ إذَا أَكَلَ أَوْ شَرِبَ هَكَذَا فِي النَّهْرِ الْفَائِقِ. وَالنَّاسِي عَكْسُهُ، هَكَذَا فِي النِّهَايَةِ وَالْبَحْرِ الرَّائِقِ. 

الهداية في شرح بداية المبتدي، دار احياء التراث العربي، 1: 122-123 

ولو أكل أو شرب ما يتغذى به أو ما يداوى به فعليه القضاء والكفارة 

ومن كان مريضا في رمضان فخاف إن صام ازداد مرضه أفطر وقضى 

Jadīd Fiqhī Masā’il, 1:128-129 

Kitāb al-Nawāzil, Muftiī Muḥammad Salmān Mansūrpūrī 6:385 

Islamic Permissibility of Tamiflu

Summary:

Muslims should avoid consuming Tamiflu capsules and must instead either use the suspension form or open the capsule and consume the contents of the capsule without ingesting the capsule itself. 

Question:

Are Tamiflu capsules permissible for Muslims to use?

Answer:

Bismihi Ta’ala

Tamiflu, and its generic equivalent oseltamivir, is an influenza neuraminidase inhibitor that is used for the treatment and prevention of influenza infections[i].  The medication is available in capsule and suspension forms. The suspension does not contain any Islamically unlawful ingredients and is therefore permissible for Muslims to use[ii].  The capsule form contains porcine gelatin in the capsule, which is considered Islamically unlawful to consume by most Islamic scholars[iii].   According to Islamic jurisprudence, medications with unlawful ingredients are not permissible to use unless certain conditions are met. A Muslim patient can only use impermissible medication when instructed to do so by an experienced doctor (thereby making him certain that a cure can be expected from the medication), and when an alternative permissible medication is not available[iv].

In the case of Tamiflu capsules, permissible alternatives exits.  As stated above, the suspension form is permissible to use as it lacks unlawful ingredients.  Even if the capsule form has to be used due to lack of availability or tolerance for the suspension, the capsule can be opened and the contents within the capsule can be consumed, thereby avoiding the impermissible pork gelatin used in the capsule.  As per the FDA[v]:

“If liquid Tamiflu is not available and you have capsules that give the right dose (30 mg, 45 mg or 75 mg), you may pull open the Tamiflu capsules and mix the powder with a small amount of sweetened liquid such as regular or sugar-free chocolate syrup. You don’t have to use chocolate syrup but thick, sweet liquids work best at covering up the taste of the medicine.”

Therefore, Muslims should avoid consuming Tamiflu capsules and must instead either use the suspension form or open the capsule and consume the contents of the capsule without ingesting the capsule itself. 

And Allah Knows Best

Mufti Adil Farooki, MD

Approved by Mufti Abdul Muqtadir Sikander


[i] BMJ. 2003;326(7401):1235

[ii] https://www.gene.com/download/pdf/tamiflu_prescribing.pdf

[iii] for a discussion of porcine gelatin, see the following:  https://muslimmed.org/2019/10/29/islamically-permissible-influenza-vaccines-available-in-the-us-for-2019-2020-season/

[iv] For a detailed discussion on medications with unlawful ingredients, see the following: https://muslimmed.org/category/general-articles/medication-with-unlawful-ingredients/

[v] https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tamiflu-consumer-questions-and-answers

Vaccination Against Typhoid/Enteric Fever

Prepared by Mufti Adil Farooki, MD, Shaykh Mateen Khan, MD and Dr. Ramzan Judge, PharmD

Summary:

The injectable vaccine Typhim Vi is permissible for Muslims as a vaccine for typhoid fever and is preferred over oral Vivotif.

Background:

Enteric fever, also known as “typhoid fever”, is a severe systemic illness characterized by fever and abdominal pain caused by the bacteria Salmonella enterica serotype Typhi. Typhoid fever infects roughly 21.6 million people (incidence of 3.6 per 1,000 population) and kills an estimated 200,000 people every year[1].

From the CDC[2]:

“People who are actively ill with typhoid fever and people who are carriers of the bacteria that cause typhoid fever can both spread the bacteria to other people.  When someone eats or drinks contaminated food or drink, the bacteria can multiply and spread into the bloodstream, causing typhoid fever.

Typhoid fever can be a life-threatening disease.  Symptoms of infection include persistent high fever, weakness, stomach pain, headache, diarrhea or constipation, cough, and loss of appetite.

People who do not get treatment can continue to have fever for weeks or months. As many as 30% of people who do not get treatment die from complications of typhoid fever. There are fewer antibiotic treatment options as drug-resistant typhoid bacteria has become more common in many parts of the world.

Typhoid fever is common in many regions of the world, including parts of East and Southeast Asia, Africa, the Caribbean, and Central and South America.  Typhoid fever is not common in the United States.”

CDC Indications for Vaccination:

According to the CDC, routine typhoid vaccination is not recommended in the United States, but is recommended for[3]:

  • Travelers to parts of the world where typhoid is common. (NOTE: typhoid vaccine is not 100% effective and is not a substitute for being careful about what you eat or drink.)
  • People in close contact with a typhoid carrier.
  • Laboratory workers who work with Salmonella typhi bacteria.

Vaccines Available in the United States

There are two typhoid vaccines available in the United States: Vivotif, an oral vaccine, and Typhim Vi, an injectable vaccine.

  1. Vivotif[4]
    • Manufacturer: Crucell Switzerland LTD
    • Form: capsule
    • Contains:  Viable S. typhi Ty21a, Non-viable S. typhi Ty21a,sucrose, ascorbic acid, amino acids, lactose, magnesium stearate, bovine gelatin
    • Culture Medium: digest of yeast extract, an acid digest of casein, dextrose and galactose
  2. Typhim Vi[5]
    • Manufacturer: Sanofi Pasteur
    • Form: injection
    • Contains: purified Vi polysaccharide, formaldehyde, phenol, polydimethylsiloxane, disodium phosphate, monosodium phosphate, sodium chloride, sterile water
    • Culture Medium: semi-synthetic medium. Casein derived raw materials are used early in manufacturing during the fermentation process

Discussion and Recommendations:

For Muslims who require typhoid vaccination, the injectable form, Typhim Vi, is permissible to use.  The capsule form, Vivotif, contains bovine gelatin, which is hydrolyzed collagen extracted from collagen-containing tissue like skin and bones. The cows from which this material is derived are not slaughtered in accordance with Islamic law. Due to the difference of opinion regarding bovine gelatin’s permissibility for consumption, it is preferable and more cautious for Muslims to use the injectable form of the vaccine.

From an Islamic perspective, preventing a health threat such as typhoid fever in high-risk patients is considered to be a necessity[6]. People for whom typhoid vaccination is indicated are considered to be at high risk for getting the infection with a significant potential for serious complications[7],  and infections may be difficult to treat due to rising antibiotic resistance[8]. Although the injectable form is preferred, Muslims may use the oral form if the injectable form is not accessible or is contraindicated (due to allergies or hypersensitivity).


[1] J Prev Med Hyg. 2017;58(1):E1–E8.

[2] https://www.cdc.gov/vaccines/hcp/vis/vis-statements/typhoid.html

[3] ibid

[4] https://www.fda.gov/media/75988/download

[5] https://www.fda.gov/media/75993/download

[6] For further discussion, see https://muslimmed.org/category/vaccines/use-of-vaccines-with-impermissible-ingredients/

[7] N Engl J Med. 1984;310(2):82.

[8] https://www.cdc.gov/typhoid-fever/symptoms.html

An Islamic Basis for the Use of Vaccines with Impermissible Ingredients

Prepared by Mufti Adil Farooki, MD. Approved by Mufti Abdul Muqtadir Sikander

Download PDF

Background on Vaccination

A vaccine is a “product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease”[1]. Vaccination is the process of administrating a vaccine, most commonly by an injection, with the immediate goal of achieving “active immunity” in the recipient of the vaccine.  Active immunity involves the “stimulation of the immune system to produce antigen-specific humoral (antibody) and cellular immunity”, and can last for many years, sometimes even a lifetime[2].   Vaccination benefits the immunized patient directly and also indirectly benefits unimmunized people through “community immunity”.  This occurs when there are enough people who are immune to an infection to decrease the risk of its transmission, and it also protects people who cannot receive vaccines due to young age or other contraindications[3].

Studies have shown that vaccination is one of the most effective preventative health measures.  After routine childhood vaccines were introduced, the number of cases for most vaccine-preventable diseases has dropped by over 90% in the United States[4]. According to statistical models, for children born between 1994 and 2013, it is estimated that routine vaccination will prevent 322 million illnesses, 21 million hospitalizations, and 732,000 deaths over the course of their lifetimes[5].  

Issue: Impermissible Ingredients in Vaccines

Based on the above findings the benefits of vaccination are clear.  In the United States, routine vaccination is required for public-school children in all 50 states, with possible exemptions varying by state.[6] In certain industries such as healthcare, employees are required to receive vaccination for their own protection as well as the protection of patients.   However, many vaccines contain ingredients that are considered impermissible for Muslims to consume, regardless of whether they are ingested or injected. Some examples are porcine gelatin, calf serum and material from growth mediums that include human, chicken, and monkey cells[7]. If a permissible version of a particular vaccine is not available, then a question arises: is it permissible for a Muslim to receive that vaccine, given that he or she does not currently have that disease and is not guaranteed to be infected by it in the future?  

Principle: Necessity Permits the Unlawful

A general principle in Islamic law is that: “الضرورات تبيح المحظورات”, or “necessity permits the forbidden”, to the extent of the need[8].  Preservation of health and safeguarding of possessions are considered to be a necessity (ضرورة), and this includes protection from serious illness and death.  Something that is otherwise unlawful can be allowed to occur when a person fears that his health or possessions would be harmed, even if he does not have absolute certainty the harm will actually occur.  In other words, the expectation of a particular outcome (غلبة الظن) is considered to be sufficient. According to the principles of Islamic law, this “expectation” is simply defined as thinking that an outcome is more likely to occur than not occur. [9]  In other words, if there is greater than a 50% expectation that a particular outcome will occur, then this is considered to be “ غلبة الظن ”.

For example:

  • If a person is sick and (based on his experience or on the advice of a doctor) he expects to get worse if he fasts during Ramadan, he would be excused from fasting that day and can make up the fast after Ramadan.[10] 
  • If a person is sick and he expects (based on his experience or the advice of a doctor) that performing wudu would make his sickness worse or prolong it, he can perform tayammum[11]
  • A person performing salah must break his salah if he fears that a blind person may fall into danger and he is able to prevent that person from falling into harm. [12]
  • A person performing salah can break his salah if he fears that a thief will steal his possessions if he were to remain busy in prayer[13]

The Importance of Avoiding Populational Harm

These examples apply to the preservation of an individual’s health and safeguarding of possessions. In each case, the threat of harm to an individual (ضررخاص) permitted something that is normally unlawful. According to the principles of Islamic law, the preservation of populational health and wealth is even more important and emphasized.  Therefore, avoiding populational harm is given preference to avoiding harm to an individual[14]. There are numerous examples in which something that is otherwise unlawful and causes harm to an individual is allowed or even required to occur in order to preserve the health and wealth of (i.e. prevent harm to) a group of people[15].  This applies even when there is an expectation (غلبة الظن) of some populational harm, not only when the harm is already occurring or is certain to occur.[16]   Examples include:

  • Forcing landowners to create a dam around a river on their property when there is fear that the water will flood and harm other people[17],[18],[19]
  • Putting restrictions on the type of business transactions that a person can engage in when it is feared that he will harm others by his reckless spending habits, cheating or inability to conform with rules of Islamic law[20]
  • Preventing a doctor from practicing or a judge from ruling due to their ineptitude in order to prevent potential harm to others
  • Forcibly taking down the wall of a privately-owned building when the wall is leaning on a public path and there is fear that it will collapse onto the path and harm people[21]
  • Forcibly selling the possessions of a person in debt in order to avoid continued harm to those whom he owes money [22]
  • Forcibly selling the food of a person who is hoarding it in times of famine in order to aid the general population, even if he refuses to sell it[23]

Application of these Principles to Vaccination

The examples above illustrate the following principles of Islamic law:

  1. Necessity permits the unlawful, to the extent of the need
  2. Preservation of health is considered to be a necessity, therefore avoiding serious threats to health is also considered to be a necessity
  3. An expectation of harm is sufficient to be considered as a threat to health, defined as being more likely than not that the harm would occur (greater than 50% expectation).
  4. Based on #2 and #3, an expectation of harm can be considered necessary to avoid and therefore can allow for the unlawful to be permitted when there is no permissible alternative
  5. The preservation of populational health is emphasized more than the preservation of individual health

Based on these principles, we have seen that in order to prevent a potential harm to the larger population (ضرر عام), a subset of the population is subjected to something that is normally unlawful (ضرر خاص).  These principles can be applied to determine if Muslims can use vaccines when there is only an impermissible version of the vaccine available.  If it is determined that a necessity (ضرورة) exists, then this vaccine would be administered to a portion of the population in order to prevent harm (in terms of morbidity/mortality) to the general population.  In other words, something that is unlawful and involves consumption of impermissible ingredients (ضرر خاص) would be permitted to be used in order to prevent harm to the greater population (ضرر عام) if necessity is established.  

Also, as in the examples discussed, there is an expectation (غلبة الظن) that the harm will occur, but not certainty.  This expectation of harm is based on the known epidemiology of the infection and on clinical trials.  And as in the examples above, the use of something that is unlawful is only allowed to the extent of the need.  In the case of vaccination, if a version of the vaccine with permissible ingredients becomes available, then it would no longer be necessary to use versions with impermissible ingredients to achieve immunization. In that case, Muslims would be required to only use the version with permissible ingredients. This is in line with rulings given by contemporary Islamic scholars stating that vaccines with impermissible ingredients can be used when there is no permissible alternative if there is a need to use the vaccine. 

Variables to Consider for an Infectious Disease and its Vaccine

In order to apply these principles to an infectious disease, it is necessary to establish that there is a necessity (ضرورة) to be immunized from it. Multiple variables need to be considered in order to establish this, such as:

  • Morbidity and Mortality

This data needs to be analyzed in order to understand the level of necessity (ضرورة)  for immunization from that infection.  The examples discussed earlier do not mention a specific number of people that need to be saved from death or illness, but rather stress the importance of preventing harm to a group of people.  In these examples, only a small group of people was threatened compared to the general population, such as in the case of a structure being removed if an unstable wall threatens people passing by, and this was still considered to be potential populational harm (ضرر عام).   In the case of infectious diseases, medical data needs to show that there is a significant impact on the morbidity and mortality of the population, such as serious illness requiring hospitalization or resulting in death.

  • Population-Specific Data

The level of risk to the general vs specific populations needs to be analyzed.  In some cases, the level of morbidity and mortality may not affect a significant proportion of the general population but may be higher in a subset of the population. An example would be the pneumococcal vaccine for adults, which is recommended for ages 65 and above and those with certain chronic medical conditions[24].  In these subsets of the population, there is a greater prevalence of and risk of complications from the infection compared to healthy adults under 65.  Therefore, the data may show that necessity (ضرورة)  for the vaccine is limited to a subset of the population. 

  • Effectiveness of the Vaccine

Data on the impact of the vaccine on reducing the morbidity and mortality of an infection needs to be analyzed.  In the examples we have discussed, an unlawful action can be allowed due to necessity only because it is expected to prevent a harm.  For this to apply to a vaccine, data needs to support that there is a significant decrease in the morbidity or mortality from the infection that is immunized against.

Example: Data for Routine Childhood Vaccinations

Routine childhood vaccination under the “Vaccines for Children” program began in 1993 and initially included vaccines for diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b disease, hepatitis B, measles, mumps, and rubella. Five additional vaccines were later added to the program: influenza, hepatitis A, varicella, pneumococcal disease, rotavirus.  The program provides cost-free vaccines to children in the United States who lack health insurance or are otherwise unable to pay for vaccines[25].  Data was analyzed for vaccines administered through this program, and as mentioned above, statistical models estimate that for children born between 1994 and 2013, 21 million hospitalizations and 732,000 deaths will be prevented during their lifetimes.  Data for each individual infection is presented in the table below, with cases measured in the thousands:

(Click image to enlarge. Table is reproduced from MMWR 2014 Apr;63(16):352-5.)

Applying the principles discussed earlier, we first need to establish that there is a necessity (ضرورة) for immunization from diseases for which vaccination with impermissible ingredients is being considered.  As stated above, this can be established by data on morbidity and mortality, both of which can be derived from the table above.  Serious illness requiring hospitalization and deaths represent morbidity and mortality from these infections that would be expected to occur (غلبة الظن) if the vaccine was not administered. 

We also need to establish that the vaccine is effective in removing the expected harm from the infection.   The data above can be used for this purpose as well, as it represents morbidity and mortality that is expected to be prevented by the use of each vaccine. 

We also need to determine if there is a need to use a form of a vaccine that has Islamically impermissible ingredients. This can be determined by analyzing the ingredients of each form that is available on the market and accessible to patients.  If a form of the vaccine with permissible ingredients is available, then there would be no need to use the one with impermissible ingredients.  For example, analysis of influenza vaccines for the 2019-2020  flu season found that permissible forms are available in the United States[26]. Therefore, impermissible forms cannot be used by Muslims unless an impermissible form is specifically required in individual circumstances. 

Some vaccines are only available in combination with others.  In that case, the combined data for the infections that are immunized against should be considered. 

Below are some examples of infections for which necessity (ضرورة) can be established based on the data presented. In each case, the data leads to an expectation (غلبة الظن) of significant populational harm (ضرر عام):

  1. Diphtheria, Tetanus, Pertussis: the vaccine for diphtheria is only available in combination with either tetanus or tetanus and pertussis for young children in the United States[27]. In combination, these infections are expected to cause approximately 7.8 million hospitalizations and 528,000 deaths if the vaccine is not given. 
  2. Measles, Mumps, Rubella: the vaccines for these infections are only available in combinations in the United States[28].  In combination, these 3 infections are expected to cause approximately 144 million hospitalizations and 58,000 deaths if the vaccine is not given. 
  3. Hepatitis B: this infection is expected to cause 623,000 hospitalizations and approximately 60,000 deaths if the vaccine is not given
  4. Pneumococcus-related diseases:  Infections in the form of pneumonia, otitis media and invasive disease are expected to cause approximately 900,000 hospitalizations and 55,000 deaths if the vaccine was not given

Once necessity (ضرورة) is established for immunization from these infections, then further investigation into the available forms of the vaccines for these infections can be done to determine if Muslims have permissible options, or if an impermissible form must be used, as discussed above.

Conditions for Applicability

For a vaccine that contains impermissible ingredients to be considered permissible to use, the following conditions must be met:

  1. Need for immunization from the infection– this can be established based on epidemiologic data on morbidity and mortality
  2. Definition of the Target Population: is the need for immunization established for the general population vs a subset of the population?
  3. Effectiveness of Vaccine: The vaccine needs to have a significant impact on the morbidity/mortality of the target population
  4. Lack of availability of a permissible alternative – if a form of a particular vaccine is produced and is accessible for the target population, then there would no longer be a necessity to use the impermissible form

Limitations

This work is not meant to be a legal verdict (or fatwa) regarding the permissibility of any specific vaccine.  Rather, it provides a legal basis upon which a potential verdict can be given.  A verdict can be given for a particular vaccine based on analysis of medical data and based on recommendations of medical personal in consultation with Islamic scholars

Conclusion

Based on the principles of avoiding populational harm and of necessity permitting the unlawful, Muslims may receive necessary vaccines with impermissible ingredients when there is no alternative form with permissible ingredients. 


[1] CDC: Immunization: The Basics. https://www.cdc.gov/vaccines/vac-gen/imz-basics.htm

[2] CDC: Principles of Vaccination. https://www.cdc.gov/vaccines/pubs/pinkbook/prinvac.html

[3] Meissner HC. Why is herd immunity so important, AAP News. 2015;36:14

[4] https://www.immunize.org/catg.d/p4037.pdf

[5] Whitney CG, Zhou F, Singleton J, Schuchat A, Centers for Disease Control and Prevention (CDC). Benefits from immunization during the vaccines for children program era – United States, 1994-2013, MMWR 2014 Apr;63(16):352-5.

[6] States With Religious and Philosophical Exemptions From School Immunization Requirements,  http://www.ncsl.org/research/health/school-immunization-exemption-state-laws.aspx

[7] CDC: Vaccine Excipient Summary. https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/b/excipient-table-2.pdf

[8] الْأَشْبَاهُ وَالنَّظَائِرُ, دار الكتب العلمية   1:73

وَهَذِهِ الْقَاعِدَةُ مَعَ الَّتِي قَبْلَهَا مُتَّحِدَةٌ أَوْ مُتَدَاخِلَةٌ، وَتَتَعَلَّق بِهَا قَوَاعِدُ: الْأُولَى: الضَّرُورَاتُ تُبِيحُ الْمَحْظُورَاتِ،

وَمِنْ ثَمَّ جَازَ أَكْلُ الْمَيْتَةِ عِنْدَ الْمَخْمَصَةِ، وَإِسَاغَةُ اللُّقْمَةِ بِالْخَمْرِ، وَالتَّلَفُّظُ بِكَلِمَةِ الْكُفْرِ لِلْإِكْرَاهِ وَكَذَا إتْلَافُ الْمَالِ، وَأَخْذُ مَالِ الْمُمْتَنِعِ الْأَدَاءِ مِنْ الدَّيْنِ بِغَيْرِ إذْنِهِ وَدَفْعُ الصَّائِلِ، وَلَوْ أَدَّى إلَى قَتْلِهِ.

[9], دار الفكر القواعد الفقهية وتطبيقاتها في المذاهب الأربعة   1:97

والشك: هو التردد بين النقيضين بلا ترجيح لأحدهما على الآخر، أو هو التردد في وقوع الشيء وعدم وقوعه على السواء، وبينه وبين اليقين الظن، أو الظن الغالب.

وهو ترجيح أحد الطرفين على الآخر بدليل ظاهر يبني عليه العاقل أموره، لكن لم يطرح الاحتمال الآخر، ويقابل الظنَّ الوهمُ، وهو الجانب المرجوح لدليل أقوى منه، والفقهاء يريدون بالشك مطلق التردد سواء كان الطرفان سواء أو أحدهما راجحاً، وعلماء الأصول يفرقون بين الشك والظن.

[10] رد المحتار على الدر المختار, دار الفكر  2:422

[10] (قَوْلُهُ خَافَ الزِّيَادَةَ) أَوْ إبْطَاءَ الْبُرْءِ أَوْ فَسَادَ عُضْوٍ بِحَرٍّ أَوْ وَجَعَ الْعَيْنِ أَوْ جِرَاحَةً أَوْ صُدَاعًا أَوْ غَيْرَهُ، وَمِثْلُهُ مَا إذَا كَانَ يُمَرِّضُ الْمَرْضَى قُهُسْتَانِيٌ ط أَيْ بِأَنْ يَعُولَهُمْ وَيَلْزَمَ مِنْ صَوْمِهِ ضَيَاعُهُمْ وَهَلَاكُهُمْ لِضَعْفِهِ عَنْ الْقِيَامِ بِهِمْ إذَا صَامَ (قَوْلُهُ وَصَحِيحٍ خَافَ الْمَرَضَ) أَيْ بِغَلَبَةِ الظَّنِّ كَمَا يَأْتِي، فَمَا فِي شَرْحِ الْمَجْمَعِ مِنْ أَنَّهُ لَا يُفْطِرُ مَحْمُولٌ عَلَى أَنَّ الْمُرَادَ بِالْخَوْفِ مُجَرَّدُ الْوَهْمِ كَمَا فِي الْبَحْرِ وَالشُّرُنْبَلاليّ (قَوْلُهُ وَخَادِمَةٍ) فِي الْقُهُسْتَانِيِّ عَنْ الْخِزَانَةِ مَا نَصُّهُ إنَّ الْحُرَّ الْخَادِمَ أَوْ الْعَبْدَ أَوْ الذَّاهِبَ لِسَدِّ النَّهْرِ أَوْ كَرْيِهِ إذَا اشْتَدَّ الْحَرُّ وَخَافَ الْهَلَاكَ فَلَهُ الْإِفْطَارُ كَحُرَّةٍ أَوْ أَمَةٍ ضَعُفَتْ لِلطَّبْخِ أَوْ غَسْلِ الثَّوْبِ

[11]رد المحتار على الدر المختار, دار الفكر    1:233

(أَوْ لِمَرَضٍ) يَشْتَدُّ أَوْ يَمْتَدُّ بِغَلَبَةِ ظَنٍّ أَوْ قَوْلِ حَاذِقٍ مُسْلِمٍ وَلَوْ بِتَحَرُّكٍ

[12] درر الحكام شرح غرر الأحكام, دار إحياء الكتب العربية  1:109       

وَيَجُوزُ قَطْعُهَا بِسَرِقَةٍ مَا يُسَاوِي دِرْهَمًا وَلَوْ لِغَيْرِهِ وَخَوْفِ ذِئْبٍ عَلَى غَنَمٍ أَوْ خَوْفِ تَرَدِّي أَعْمَى فِي بِئْرٍ وَيَجِبُ قَطْعُهَا بِاسْتِغَاثَةِ مَلْهُوفٍ مَظْلُومٍ بِالْمُصَلِّي وَلَا يَجِبُ قَطْعُهَا بِنِدَاءِ أَحَدِ أَبَوَيْهِ اهـ قَالَ الْوَلْوَالِجِيُّ إلَّا أَنْ يَسْتَغِيثَ بِهِ أَيْ أَحَدُ أَبَوَيْهِ وَهَذَا فِي الْفَرْضِ فَأَمَّا فِي النَّفْلِ إذَا نَادَاهُ أَحَدُ أَبَوَيْهِ إنْ عَلِمَ أَنَّهُ فِي الصَّلَاةِ لَا بَأْسَ أَنْ لَا يُجِيبَهُ، وَإِنْ لَمْ يَعْلَمْ يُجِيبُهُ كَمَا فِي الْبَحْرِ اهـ.

[13] رد المحتار على الدر المختار, دار الفكر    2:52

مطلب قطع الصلاة يكون حراما ومباحا ومستحبا وواجبا.[تتمة] نقل عن خط صاحب البحر على هامشه أن القطع يكون حراما ومباحا ومستحبا وواجبا، فالحرام لغير عذر والمباح إذا خاف فوت مال، والمستحب القطع للإكمال، والواجب لإحياء نفس.

[14]  الْأَشْبَاهُ وَالنَّظَائِرُ, دار الكتب العلمية     1:75

تَنْبِيهٌ: يُتَحَمَّلُ الضَّرَرُ الْخَاصُّ؛ لِأَجْلِ دَفْعِ ضَرَرِ الْعَامِّ. وَهَذَا مُقَيِّدٌ لِقَوْلِهِمْ: الضَّرَرُ لَا يُزَالُ بِمِثْلِهِ

[15]  تبيين الحقائق شرح كنز الدقائق وبهامشه حاشية الشلبي, المطبعة الكبرى الأميرية   6:40

(قَوْلُهُ: وَالْفَاصِلُ بَيْنَ الْخَاصِّ وَالْعَامِّ إلَخْ) قَالَ الْأَتْقَانِيُّ وَجَعَلَ مُحَمَّدٌ الْحَدَّ الْفَاصِلَ بَيْنَ الْعَامِّ وَالْخَاصِّ اسْتِحْقَاقَ الشُّفْعَةِ فَقَالَ الْخَاصُّ مِنْ النَّهْرِ مَا لَوْ بِيعَتْ أَرْضٌ عَلَى هَذَا النَّهْرِ كَانَ لِجَمِيعِ أَهْلِ النَّهْرِ حَقُّ الشُّفْعَةِ فَيَحْتَاجُ إلَى أَنْ يَذْكُرَ الْحَدَّ الْفَاصِلَ بَيْنَ الشَّرِكَةِ الْعَامَّةِ وَالْخَاصَّةِ فِي الشُّفْعَةِ وَاخْتَلَفَ الْمَشَايِخُ فِي تَحْدِيدِ ذَلِكَ، وَلَكِنْ أَحْسَنُ مَا قِيلَ فِيهِ مِنْ التَّحْدِيدِ هُوَ أَنَّ الشُّرَكَاءَ فِي النَّهْرِ إنْ كَانُوا مَا دُونَ الْمِائَةِ فَالشَّرِكَةُ خَاصَّةٌ تُسْتَحَقُّ بِهَا الشُّفْعَةُ، وَإِنْ كَانُوا مِائَةً فَصَاعِدًا فَالشَّرِكَةُ عَامَّةٌ لَا تَجِبُ الشُّفْعَةُ لِلْكُلِّ، وَإِنَّمَا تَكُونُ لِلْجَارِ. اهـبَيْنَ الْخَاصِّ وَالْعَامِّ أَنَّ مَا تُسْتَحَقُّ بِهِ الشُّفْعَةُ خَاصٌّ، وَمَا لَا تُسْتَحَقُّ بِهِ عَامٌّ. وَوَجْهُ الْفَرْقِ بَيْنَهُمَا أَنَّ فِي الْعَامِّ دَفْعَ الضَّرَرِ الْعَامِّ، وَهُوَ ضَرَرُ بَقِيَّةِ الشُّرَكَاءِ، وَمِثْلُ هَذَا جَائِزٌ بِإِلْزَامِ الضَّرَرِ الْخَاصِّ بَلْ وَاجِبٌ إذَا تَعَيَّنَ مِدْفَعًا فَبِدُونِ الضَّرَرِ أَوْلَى؛ لِأَنَّ الْآبِيَ لَا يَلْحَقُهُ بِذَلِكَ ضَرَرٌ بَلْ يَحْصُلُ لَهُ نَفْعٌ بِمُقَابَلَتِهِ فَأَمْكَنَ إجْبَارُهُ عَلَيْهِ بِخِلَافِ مَا إذَا كَانَ خَاصًّا؛ لِأَنَّهُ لَيْسَ فِيهِ دَفْعُ ضَرَرٍ عَامٍّ، وَإِنَّمَا فِيهِ دَفْعُ ضَرَرٍ خَاصٍّ، وَهُوَ ضَرَرُ شُرَكَائِهِ فَلَا يَلْزَمُهُ الضَّرَرُ الْخَاصُّ لِدَفْعِ الضَّرَرِ الْخَاصِّ؛ لِأَنَّهُمَا اسْتَوَيَا، وَيُمْكِنُ دَفْعُ ضَرَرِ شُرَكَائِهَا بِدُونِ ذَلِكَ بِأَنْ يَرْجِعُوا عَلَيْهِ بِحِصَّتِهِ مِنْ الْمُؤْنَةِ إذَا كَانَ ذَلِكَ بِأَمْرِ الْقَاضِي بِخِلَافِ مَا إذَا كَانَ عَامًّا؛ لِأَنَّهُ لَا يُمْكِنُهُ الرُّجُوعُ عَلَيْهِمْ لِكَثْرَتِهِمْ وَرُبَّمَا لَا تُقْبَلُ الْمُؤْنَةُ الْقِسْمَةَ عَلَيْهِمْ، وَلَا يَدْرِي حِصَّةَ كُلِّ وَاحِدٍ مِنْهُمْ

[16]رد المحتار على الدر المختار, دار الفكر  2:422

ط (قَوْلُهُ بِغَلَبَةِ الظَّنِّ) تُنَازِعُهُ خَافَ الَّذِي فِي الْمَتْنِ وَخَافَ وَخَافَتْ اللَّتَانِ فِي الشَّرْحِ ط (قَوْلُهُ بِأَمَارَةٍ) أَيْ عَلَامَةٍ (قَوْلُهُ أَوْ تَجْرِبَةٍ) وَلَوْ كَانَتْ مِنْ غَيْرِ الْمَرِيضِ عِنْدَ اتِّحَادِ الْمَرَضِ ط عَنْ أَبِي السُّعُودِ (قَوْلُهُ حَاذِقٍ) أَيْ لَهُ مَعْرِفَةٌ تَامَّةٌ فِي الطِّبِّ، فَلَا يَجُوزُ تَقْلِيدُ مَنْ لَهُ أَدْنَى مَعْرِفَةٍ فِيهِ ط (قَوْلُهُ مُسْلِمٍ) أَمَّا الْكَافِرُ فَلَا يُعْتَمَدُ عَلَى قَوْلِهِ لِاحْتِمَالِ أَنَّ غَرَضَهُ إفْسَادُ الْعِبَادَةِ كَمُسْلِمٍ شَرَعَ فِي الصَّلَاةِ بِالتَّيَمُّمِ فَوَعَدَهُ بِإِعْطَاءِ الْمَاءِ فَإِنَّهُ لَا يَقْطَعُ الصَّلَاةَ لِمَا قُلْنَا بَحْرٌ (قَوْلُهُ مَسْتُورٍ) وَقِيلَ عَدَالَتُهُ شَرْطٌ وَجَزَمَ بِهِ الزَّيْلَعِيُّ وَظَاهِرُ مَا فِي الْبَحْرِ وَالنَّهْرِ ضَعْفُهُ ط.

[17]  المبسوط السرخسي, دار المعرفة  20:159

وَلَوْ أَنَّ نَهْرًا بَيْنَ قَوْمٍ فَاصْطَلَحُوا عَلَى كَرْيِهِ أَوْ بِوَضْعِ مَمْشَاةٍ أَوْ قَنْطَرَةٍ عَلَيْهِ عَلَى أَنْ يَكُونَ النَّفَقَةُ عَلَيْهِمْ بِحِصَصِهِمْ فَهَذَا جَائِزٌ كُلُّهُ عَلَيْهِمْ؛ لِأَنَّهُمْ يُجْبَرُونَ عَلَى ذَلِكَ لَوْ لَمْ يَصْطَلِحُوا إذَا كَانَ فِيهِ ضَرَرٌ عَامٌّ فَإِنَّ رَفْعَ الضَّرَرِ وَاجِبٌ فَإِذَا اصْطَلَحُوا كَانَ إلَى الْجَوَازِ أَقْرَبُ فَإِنْ كَانَ بِحَيْثُ لَا يَضُرُّهُمْ تَرْكُهَا فَفِي الْقَنْطَرَةِ وَالْمَمْشَاةِ لَا يُجْبَرُونَ عَلَى ذَلِكَ؛ لِأَنَّهُ تَدْبِيرٌ فِي الْمِلْكِ وَهُوَ مُفَوَّضٌ إلَى رَأْيِ الْمُلَّاكِ وَإِنَّمَا يُجْبَرُونَ عَلَى إزَالَةِ الضَّرَرِ الْعَامِّ فَمَا لَيْسَ فِيهِ ضَرَرٌ عَامٌّ لَا يُجْبَرُونَ عَلَيْهِ وَأَمَّا الْكَرْيُ فَإِنِّي أُجْبِرُ عَلَيْهِ؛ لِأَنَّ فِي تَرْكِهِ ضَرَرًا عَامًّا فَإِنَّ لِلنَّاسِ فِي النَّهْرِ حَقَّ السَّقْيِ فَيَتَضَرَّرُونَ بِانْقِطَاعِ ذَلِكَ عَنْهُمْ وَلَا يَصِلُ إلَيْهِمْ مِلْكُ الْمَنْفَعَةِ إلَّا بِالْكَرْيِ وَلِلْإِمَامِ أَنْ يُجْبِرَ الشُّرَكَاءَ فِيهِ عَلَى الْكَرْيِ وَتَمَامُ هَذَا فِي كِتَابِ الشِّرْبِ.

[18]  بدائع الصنائع في ترتيب الشرائع, دار الكتب العلمية  6:191

وَلَوْ زَادَ فِي عَرْضِهِ لَا يَجُوزُ؛ لِأَنَّ الْكُوَى مِنْ حُقُوقِ النَّهْرِ فَيَمْلِكُهُ بِمِلْكِ النَّهْرِ بِخِلَافِ الزِّيَادَةِ فِي الْعَرْضِ، وَلَوْ كَانَ نَهْرٌ يَأْخُذُ الْمَاءَ مِنْ النَّهْرِ الْأَعْظَمِ بَيْنَ قَوْمٍ فَخَافُوا أَنْ يَنْبَثِقَ فَأَرَادُوا أَنْ يُحَصِّنُوهُ فَامْتَنَعَ بَعْضُهُمْ عَنْ ذَلِكَ فَإِنْ كَانَ ضَرَرًا عَامًّا يُجْبَرُونَ عَلَى أَنْ يُحَصِّنُوهُ بِالْحِصَصِ، وَإِنْ لَمْ يَكُنْ فِيهِ ضَرَرٌ عَامٌّ لَا يُجْبَرُونَ عَلَيْهِ؛ لِأَنَّ الِانْتِفَاعَ مُتَعَذَّرٌ عِنْدَ عُمُومِ الضَّرَرِ، فَكَانَ الْجَبْرُ عَلَى التَّحْصِيصِ مِنْ بَابِ دَفْعِ الضَّرَرِ عَنْ الْجَمَاعَةِ فَجَازَ وَإِذَا لَمْ يَكُنْ الضَّرَرُ عَامًّا يُمْكِنُ الِانْتِفَاعُ بِالنَّهْرِ فَكَانَ الْجَبْرُ بِالتَّحْصِيصِ جَبْرًا عَلَيْهِ لِزِيَادَةِ الِانْتِفَاعِ بِالنَّهْرِ وَهَذَا لَا يَجُوزُ وَلَوْ كَانَ نَهْرٌ لِرَجُلٍ مُلَاصِقٌ لِأَرْضِ رَجُلٍ فَاخْتَلَفَ صَاحِبُ الْأَرْضِ وَالنَّهْرِ فِي مُسَنَّاةٍ فَالْمُسَنَّاةُ لِصَاحِبِ الْأَرْضِ عِنْدَ أَبِي حَنِيفَةَ – رَحِمَهُ اللَّهُ – لَهُ أَنْ يَغْرِسَ فِيهَا طِينَهُ وَلَكِنْ لَيْسَ لَهُ أَنْ يَهْدِمَهَا.

[19] الإختيار لتعليل المختار, مطبعة الحلبي  3:72

(وَمَا هُوَ مَمْلُوكٌ لِلْعَامَّةِ فَكَرْيُهُ عَلَى أَهْلِهِ) ؛ لِأَنَّ مَنْفَعَتَهُ لَهُمْ. (وَمَنْ أَبَى مِنْهُمْ يُجْبَرُ) دَفْعًا لِلضَّرَرِ الْعَامِّ، وَهُوَ ضَرَرُ الشُّرَكَاءِ بِالضَّرَرِ الْخَاصِّ، كَيْفَ وَفِيهِ مَنْفَعَتُهُ؟ فَلَا يُعَارِضُهُ.وَإِنْ كَانَ فِيهِ ضَرَرٌ عَامٌّ بِأَنْ خَافُوا أَنْ يَنْشَقَّ النَّهْرُ، فَيَخْرُجَ الْمَاءُ إِلَى طَرِيقِ الْمُسْلِمِينَ وَأَرَاضِيهِمْ – فَعَلَيْهِمْ تَحْصِينُهُ بِالْحِصَصِ. وَالنَّهْرُ الْمَمْلُوكُ لِجَمَاعَةٍ مَخْصُوصِينَ فَكَرْيُهُ عَلَيْهِمْ، وَمَنْ أَبَى مِنْهُمْ قِيلَ: يُجْبَرُ؛ لِمَا مَرَّ، وَقِيلَ: لَا يُجْبَرُ؛ لِأَنَّ كُلَّ وَاحِدٍ مِنَ الضَّرَرَيْنِ خَاصٌّ. وَيُمْكِنُ دَفْعُهُ بِالْكَرْيِ بِأَمْرِ الْقَاضِي، ثُمَّ يَرْجِعُ عَلَى الْآبِي، وَلَا كَذَلِكَ الْأَوَّلُ

[20]  الجوهرة النيرة على مختصر القدوريي, المطبعة الخيرية  1:242

(قَوْلُهُ: وَقَالَ أَبُو حَنِيفَةَ: لَا أَحْجُرُ عَلَى السَّفِيهِ إذَا كَانَ حُرًّا بَالِغًا عَاقِلًا) السَّفِيهُ خَفِيفُ الْعَقْلِ الْجَاهِلُ بِالْأُمُورِ الَّذِي لَا تَمْيِيزَ لَهُ الْعَامِلُ بِخِلَافِ مُوجَبِ الشَّرْعِ، وَإِنَّمَا لَمْ يُحْجَرْ عَلَيْهِ عِنْدَ أَبِي حَنِيفَةَ؛ لِأَنَّهُ مُخَاطَبٌ عَاقِلٌ وَلِأَنَّ فِي سَلْبِ وِلَايَتِهِ إهْدَارَ آدَمِيَّتِهِ، وَإِلْحَاقَهُ بِالْبَهَائِمِ وَذَلِكَ أَشَدُّ عَلَيْهِ مِنْ التَّبْذِيرِ فَلَا يُحْتَمَلُ الْأَعْلَى لِدَفْعِ الْأَدْنَى إلَّا أَنْ يَكُونَ فِي الْحَجْرِ عَلَيْهِ دَفْعُ ضَرَرٍ عَامٍّ كَالْحَجْرِ عَلَى الطَّبِيبِ الْجَاهِلِ، وَالْمُفْتِي الْمَاجِنِ، وَالْمُكَارِي الْمُفْلِسِ فَإِنَّ هَؤُلَاءِ يُحْجَرُ عَلَيْهِمْ فِيمَا يُرْوَى عَنْ أَبِي حَنِيفَةَ؛ إذْ هُوَ دَفْعُ الْأَعْلَى بِالْأَدْنَى، الْمُفْتِي الْمَاجِنُ هُوَ الَّذِي يُعَلِّمُ النَّاسَ حِيَلًا بَاطِلَةً كَارْتِدَادِ الْمَرْأَةِ لِتُفَارِقَ زَوْجَهَا، أَوْ الرَّجُلِ لِيُسْقِطَ الزَّكَاةَ وَلَا يُبَالِي أَنْ يُحَلِّلَ حَرَامًا، أَوْ يُحَرِّمَ حَلَالًا. وَالطَّبِيبُ الْجَاهِلُ هُوَ أَنْ يَسْقِيَ النَّاسَ دَوَاءً مُهْلِكًا. وَالْمُكَارِي الْمُفْلِسُ أَنْ يُكْرِيَ إبِلًا وَلَيْسَتْ لَهُ إبِلٌ وَلَا مَالٌ يَشْتَرِيهَا بِهِ، وَإِذَا جَاءَ أَوَانُ الْخُرُوجِ يُخْفِي نَفْسَهُ. قَوْلُهُ: (وَتَصَرُّفُهُ فِي مَالِهِ جَائِزٌ) لِأَنَّهُ مُخَاطَبٌ عَاقِلٌ لِقَوْلِهِ

[21]  الْأَشْبَاهُ وَالنَّظَائِرُ, دار الكتب العلمية  1:75

مِنْهَا: جَوَازُ الرَّمْيِ إلَى كُفَّارٍ تَتَرَّسُوا بِصِبْيَانِ الْمُسْلِمِينَ.

وَمِنْهَا: وُجُوبُ نَقْضِ حَائِطٍ مَمْلُوكٍ مَالَ إلَى طَرِيقِ الْعَامَّةِ عَلَى مَالِكِهَا؛ دَفْعًا لِلضَّرَرِ الْعَامِّ،

وَمِنْهَا: جَوَازُ الْحَجْرِ عَلَى الْبَالِغِ الْعَاقِلِ الْحُرِّ عِنْدَ أَبِي حَنِيفَةَ رَحِمَهُ اللَّهُ فِي ثَلَاثٍ: الْمُفْتِي الْمَاجِنِ، وَالطَّبِيبِ الْجَاهِلِ، وَالْمُكَارِي الْمُفْلِسِ؛ دَفْعًا لِلضَّرَرِ الْعَامِّ

وَمِنْهَا: جَوَازُهُ عَلَى السَّفِيهِ عِنْدَهُمَا وَعَلَيْهِ الْفَتْوَى، دَفْعًا لِلضَّرَرِ الْعَامِّ.

وَمِنْهَا: بَيْعُ مَالِ الْمَدْيُونِ الْمَحْبُوسِ عِنْدَهُمَا لِقَضَاءِ دَيْنِهِ، دَفْعًا لِلضَّرَرِ عَنْ الْغُرَمَاءِ وَهُوَ الْمُعْتَمَدُ

وَمِنْهَا: التَّسْعِيرُ عِنْدَ تَعَدِّي أَرْبَابِ الطَّعَامِ فِي بَيْعِهِ بِغَبْنٍ فَاحِشٍ.

وَمِنْهَا: بَيْعُ طَعَامِ الْمُحْتَكَرِ جَبْرًا عَلَيْهِ عِنْدَ الْحَاجَةِ وَامْتِنَاعِهِ مِنْ الْبَيْعِ، دَفْعًا لِلضَّرَرِ الْعَامِّ

[22] Ibid

[23] Ibid

[24] CDC. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP), MMWR Morb Mortal Wkly Rep. 2012;61(40):816.

[25] Vaccines for Children Program (VFC), https://www.cdc.gov/vaccines/programs/vfc/index.html

[26] Shaykh Mateen Khand, MD and Ramzan Judge, PharmD. Islamically Permissible Influenza Vaccines Available in the US for 2019-2020 Season, https://muslimmed.org/category/vaccines/influenza-vaccines-2019-2020/

[27] https://www.vaccines.gov/diseases/diphtheria

[28] CDC: Vaccine Excipient Summary. https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/b/excipient-table-2.pdf

Islamically Permissible Influenza Vaccines Available in the US for 2019-2020 Season

Prepared by Shaykh Mateen A. Khan, MD and Dr. Ramzan Judge, PharmD

Summary

Permissible influenza vaccines in the US for 2019-2020 season:

  • Fluad™
  • Fluzone High-Dose™
  • Afluria™
  • Fluarix™
  • FluLaval™
  • Fluzone™ Quadrivalent

Impermissible influenza vaccines in the US for 2019-2020 season:

  • Flublok™
  • FluMist™
  • Flucelvax™

Discussion

Background on Influenza

Influenza (commonly known as the flu) is a seasonal viral illness carrying significant health, economic, and social burden. For the past nine years, the Centers for Disease Control and Prevention (CDC) estimates that every year 9.3-49 million symptomatic illnesses, 4.3-23 million medical visits, 140,000-960,000 hospitalizations, and 12,000-79,000 deaths are attributed to seasonal influenza. For the 2017-2018 season, which was considered high severity, a study estimated influenza vaccination prevented:

  • 7.1 million illnesses
  • 3.7 million medical visits
  • 109,000 hospitalizations (10% of expected overall and 41% among young children)
  • 8,000 deaths1

In addition to providing immunity to healthy individuals, the vaccine benefits the sick by decreasing the amount of exposure from other individuals (herd immunity). Hence, the CDC, along with most American medical organizations, recommends that every person above six months old receive a seasonal influenza vaccine yearly.2

Improving vaccination rates among Muslims has been a struggle. Muslim majority countries find their populations hesitant.3 Similar issues are faced among Muslim minority populations in the West over a concern for the presence of impermissible ingredients in the vaccine.4

The United States currently offers nine different commercially prepared vaccines. We reviewed package inserts and public records for the vaccines to evaluate methods of production and the presence of impermissible products. When necessary, we corresponded with the manufacturers. The results are compiled in Table 1. The vaccines vary in their methods of production and ingredients, which may pose religious challenges for Muslims.

Challenge #1 – Methods of Production

Influenza vaccines are prepared through three different processes. Most strains are prepared through an egg-based manufacturing process. This involves injecting vaccine viruses into fertilized chicken eggs. Essentially, the egg is commandeered as a factory by the viruses as they use the egg’s resources to replicate themselves. The viruses are extracted and purified.5 Islamically, this process per se is not an issue as eggs are considered permissible.

Flucelvax™, a product by Seqirus, is made by incubating influenza viruses in a particular animal cell line, Madin-Darby Canine Kidney (MDCK).6 The MDCK cell line was initially isolated in 1958 from an adult Cocker Spaniel dog.7 Dogs, like all predators, are ḥarām as Sayyidunā Ibn `Abbās (may Allah be pleased with him) narrated that Allah’s Messenger ﷺ prohibited every predator possessing canine teeth.8 Further, when cells like MDCK are removed from an animal, they are considered maytah (carrion) in Islamic terminology. The Prophet ﷺ informed us, “Whatever is cut from an animal while it is alive is carrion.”9 Surah al-An`ām states a ruling of najis and ḥarām for carrion.

“Say, “I do not find, in what has been revealed to me, anything prohibited for anyone who eats it, unless it be carrion or blood that pours forth, or flesh of swine – because it is impure.”10

Hence, the initially harvested canine cells were najis and ḥarām. Since 1958, the cell line has undergone countless replication cycles in artificial environments, and the parent cells have long died off. Still, being the progeny cells, they will be impure and impermissible.

The MDCK cells used in Flucelvax™ are grown in a medium in which no human or animal-derived materials are used.11 After an incubation period, the cells are processed through lysis, and the virus proteins undergo extraction and purification. Despite this, residual amounts of the cells capable of inducing allergic reaction in susceptible patients remain, per the package insert. For these reasons, Flucelvax™ vaccine made from this method is impermissible.

Flublok™ manufactured by Sanofi, is produced by genetically engineering proteins expressed by influenza into an alternate virus, baculovirus (Autographa californica). It is then used to infect an insect cell line (ExpresSF+) derived from the fall armyworm (Spodoptera frugiperda), which produces the desired influenza proteins. This vaccine is especially valuable to those who have allergies to eggs.12 Many insects, like the armyworm, fall into the category of al-khabā’ith explicitly mentioned in the Qur’an as ḥarām in Surah al-A`rāf.

[He ﷺ] makes unlawful for them impure things (al-khabā’ith).13

Similar to animal cell lines discussed previously, the progeny ExpresSF+ cells are impure and impermissible. Hence, Flublok™ vaccine made from this method is also impermissible.

Issue #2 – Porcine Gelatin as a Stabilizer

Two of the vaccines available in the United States, FluMist™ and Flucelvax™, contain porcine gelatin. The gelatin is added as a stabilizer for the viral vaccine protein. Gelatin is hydrolyzed collagen, which is extracted from collagen-containing tissue like skin and bones. At the outset, the Qur’an declares that all porcine parts are najis and ḥarām.

Say, “I do not find, in what has been revealed to me, anything (out of the cattle under discussion) prohibited for anyone who eats it, unless it be carrion or blood that pours forth, or flesh of swine – because it is impure – or there be an animal slaughtered sinfully by invoking on it the name of someone other than Allah. (Surah al-An`ām:145)14

He has but prohibited for you the carrion, the blood, the flesh of swine and what has been invoked upon with a name other than that of Allah. (Surah al-Naḥl:115)15

In earlier times, gelatin was prepared in homes through a process of cooking, causing the collagen to hydrolyze and break into peptides of varying lengths. Although the process today is commercialized and done through a series of chemical reactions, extraction, and purification, the result is not much different from home preparations. These peptides do not constitute a significant change from the original porcine collagen. Instead, gelatin is just fragmented hydrolyzed collagen. The resulting gelatin is impermissible.16 Hence, FluMist™ and Flucelvax™ are impermissible particularly when other permissible alternatives exist.

Exceptional Cases

If someone is unable to take one of the permissible vaccines (e.g., an egg allergy), but they are relatively healthy, they should not take an impermissible vaccine. However, if a strong need exists, then they may take those vaccines that are normally impermissible. An example of a strong medical need is when there is a high likelihood (ghalabah al-ẓann) of significant morbidity or mortality in contracting influenza such as in the very old or patients with pre-existing significant comorbidities. Ideally, the Sharī`ah prefers a competent Muslim physician to determine this need based upon the evidences at hand. The physician should be pious and have a basic understanding of the relevant Sharī`ah rulings.17 Vaccinations mandated by the government, work places, or schools may also constitute a strong need.18 In any of these situations, one may take (in order of preference) Flublok™, FluMist™, and Flucelvax™.

Conclusion

Of the nine commercially available influenza vaccines available in the US for the 2019-2020 season, six are Islamically permissible: Fluad™, Fluzone High-Dose™, Afluria™, Fluarix™, FluLaval™, and Fluzone™ Quadrivalent. The Muslim public is advised to avoid Flublok™, FluMist™, and Flucelvax™.

In exceptional cases, as outlined above, one may take Flublok™, FluMist™, and Flucelvax™ in that order.

Of note, vaccine formulations are subject to change year to year. The research presented here is accurate for the 2019-2020 season.

Acknowledgment

We request Allah ta`āla to send special blessings on Mufti Faisal al-Mahmudi for his invaluable assistance.

Table 1: 2019-2020 Influenza Vaccines

Rolfes, M.A. (2019). Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season. Clinical Infectious Diseases, ciz075, doi.org/10.1093/cid/ciz075.

https://www.cdc.gov/flu/prevent/whoshouldvax.htm

Ahmed, A. (2018) Outbreak of vaccine-preventable diseases in Muslim majority countries. Journal of Infection and Public Health, 11 (2), 153-155. doi.org/10.1016/j.jiph.2017.09.007

https://mcb.org.uk/mcb-updates/position-on-flu-vaccines/.

https://www.cdc.gov/flu/prevent/how-fluvaccine-made.htm#targetText=The%20most%20common%20way%20that,for%20more%20than%2070%20years.&targetText=For%20flu%20shots%2C%20the%20influenza,and%20virus%20antigen%20is%20purified.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177469/

https://en.wikipedia.org/wiki/Madin-Darby_Canine_Kidney_cells#targetText=Madin%2DDarby%20Canine%20Kidney%20(MDCK,as%20responses%20to%20growth%20factors.

عَنِ ابْنِ عَبَّاسٍ، قَالَ نَهَى رَسُولُ اللَّهِ صلى الله عليه وسلم عَنْ كُلِّ ذِي نَابٍ مِنَ السِّبَاعِ (مسلم 1934)

مَا قُطِعَ مِنَ الْبَهِيمَةِ وَهِيَ حَيَّةٌ فَهِيَ مَيْتَةٌ (أبو داوود 2858، الترمذي 1480، ابن ماجه 3216)
وَعَلَى هَذَا يَخْرُجُ مَا إذَا قَطَعَ مِنْ أَلْيَةِ الشَّاةِ قِطْعَةً أَوْ مِنْ فَخِذِهَا أَنَّهُ لَا يَحِلُّ الْمُبَانُ وَإِنْ ذُبِحَتْ الشَّاةُ بَعْدَ ذَلِكَ؛ لِأَنَّ حُكْمَ الذَّكَاةِ لَمْ يَثْبُتْ فِي الْجُزْءِ الْمُبَانِ وَقْتَ الْإِبَانَةِ لِانْعِدَامِ ذَكَاةِ الشَّاةِ لِكَوْنِهَا حَيَّةً وَقْتَ الْإِبَانَةِ، وَحَالَ فَوَاتِ الْحَيَاةِ كَانَ الْجُزْءُ مُنْفَصِلًا وَحُكْمُ الذَّكَاةِ لَا يَظْهَرُ فِي الْجُزْءِ الْمُنْفَصِلِ وَرُوِيَ أَنَّ أَهْلَ الْجَاهِلِيَّةِ كَانُوا يَقْطَعُونَ قِطْعَةً مِنْ أَلْيَةِ الشَّاةِ وَمِنْ سَنَامِ الْبَعِيرِ فَيَأْكُلُونَهَا فَلَمَّا بُعِثَ النَّبِيُّ الْمُكَرَّمُ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – نَهَاهُمْ عَنْ ذَلِكَ فَقَالَ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «مَا أُبِينَ مِنْ الْحَيِّ فَهُوَ مَيِّتٌ» وَالْجُزْءُ الْمَقْطُوعُ مُبَانٌ مِنْ حَيٍّ وَبَائِنٌ مِنْهُ فَيَكُونُ مَيِّتًا وَكَذَلِكَ إذَا قُطِعَ ذَلِكَ مِنْ صَيْدٍ لَمْ يُؤْكَلْ الْمَقْطُوعُ، وَإِنْ مَاتَ الصَّيْدُ بَعْدَ ذَلِكَ لِمَا قُلْنَا. (بدائع الصنائع في ترتيب الشرائع)

10 عَ قُل لَّا أَجِدُ فِي مَا أُوحِيَ إِلَيَّ مُحَرَّمًا عَلَىٰ طَاعِمٍ يَطْعَمُهُ إِلَّا أَن يَكُونَ مَيْتَةً أَوْ دَمًا مَّسْفُوحًا أَوْ لَحْمَ خِنزِيرٍ فَإِنَّهُ رِجْسٌ أَوْ فِسْقًا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

11 European Medicines Agency Assessment Report on Flucelvax Tetra. 18 Oct. 2018. Pg. 14.

12 Barr, I. G. (2018). Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness. NPJ vaccines, 3, 44. doi:10.1038/s41541-018-0079-z

13 وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ
(وَأَمَّا) الَّذِي يَعِيشُ فِي الْبَرِّ فَأَنْوَاعٌ ثَلَاثَةٌ: مَا لَيْسَ لَهُ دَمٌ أَصْلًا، وَمَا لَيْسَ لَهُ دَمٌ سَائِلٌ، وَمَا لَهُ دَمٌ سَائِلٌ مِثْلُ الْجَرَادِ وَالزُّنْبُورِ وَالذُّبَابِ وَالْعَنْكَبُوتِ وَالْعَضَّابَةِ وَالْخُنْفُسَاءِ وَالْبُغَاثَةِ وَالْعَقْرَبِ.
وَنَحْوِهَا لَا يَحِلُّ أَكْلُهُ إلَّا الْجَرَادَ خَاصَّةً؛ لِأَنَّهَا مِنْ الْخَبَائِثِ لِاسْتِبْعَادِ الطِّبَاعِ السَّلِيمَةِ إيَّاهَا وَقَدْ قَالَ اللَّهُ تَبَارَكَ وَتَعَالَى {وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ} [الأعراف: 157] إلَّا أَنَّ الْجَرَادَ خُصَّ مِنْ هَذِهِ الْجُمْلَةِ بِقَوْلِهِ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «أُحِلَّتْ لَنَا مَيْتَتَانِ» فَبَقِيَ عَلَى ظَاهِرِ الْعُمُومِ. وَكَذَلِكَ مَا لَيْسَ لَهُ دَمٌ سَائِلٌ مِثْلُ الْحَيَّةِ وَالْوَزَغِ وَسَامِّ أَبْرَصَ وَجَمِيعِ الْحَشَرَاتِ وَهَوَامِّ الْأَرْضِ مِنْ الْفَأْرِ وَالْقُرَادِ وَالْقَنَافِذِ وَالضَّبِّ وَالْيَرْبُوعِ وَابْنِ عِرْسٍ وَنَحْوِهَا، وَلَا خِلَافَ فِي حُرْمَةِ هَذِهِ الْأَشْيَاءِ إلَّا فِي الضَّبِّ (بدائع الصنائع في ترتيب الشرائع)

14 قُل لَّا أَجِدُ فِي مَا أُوحِيَ إِلَيَّ مُحَرَّمًا عَلَىٰ طَاعِمٍ يَطْعَمُهُ إِلَّا أَن يَكُونَ مَيْتَةً أَوْ دَمًا مَّسْفُوحًا أَوْ لَحْمَ خِنزِيرٍ فَإِنَّهُ رِجْسٌ أَوْ فِسْقًا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

15 إِنَّمَا حَرَّمَ عَلَيْكُمُ الْمَيْتَةَ وَالدَّمَ وَلَحْمَ الْخِنزِيرِ وَمَا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

16 Respectfully, the minority opinion considering gelatin to have undergone a significant transformation (tabdīl al-mahiyah) rendering its ruling changed seems doubtful for the reasons outlined. This is an extensive discussion. However, with the availability of clearly ḥalāl alternatives, the opinion given in this article is more cautious.

17 وَجَوَّزَهُ فِي النِّهَايَةِ بِمُحَرَّمٍ إذَا أَخْبَرَهُ طَبِيبٌ مُسْلِمٌ أَنَّ فِيهِ شِفَاءً وَلَمْ يَجِدْ مُبَاحًا يَقُومُ مَقَامَهُ. قُلْت: وَفِي الْبَزَّازِيَّةِ وَمَعْنَى قَوْلِهِ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «إنَّ اللَّهَ لَمْ يَجْعَلْ شِفَاءَكُمْ فِيمَا حُرِّمَ عَلَيْكُمْ» نَفْيُ الْحُرْمَةِ عِنْدَ الْعِلْمِ بِالشِّفَاءِ دَلَّ عَلَيْهِ جَوَازُ شُرْبِهِ لِإِزَالَةِ الْعَطَشِ (رد المحتار على الدر المختار)

18 Imdād al-Fatāwa Jadīd ma`a Hāshiyah Shabbīr Aḥmad al-Qāsimī, 9:262

Opioid Medications

Question:  Is the use of opioid drugs such as oxycodone and codeine for medicinal purposes permissible?

Answer:

Bismihi Ta’ala

Opioid drugs are those that are derived from opium.  These drugs are used for various medicinal purposes, such as relief of pain or cough. Common side effects of opioid medications include constipation, nausea, vomiting, sedation, impaired psychomotor function, and urinary retention. 

In general, the consumption of intoxicating substances is impermissible according to the shariah.  Intoxication is defined in shariah as a state in which a person is insane and this can be as extreme as not being able to differentiate the sky from the ground. At a minimum, a person is considered to be intoxicated if the majority of his speech is non-sensical.[i][ii]

A state of delirium that would fit the criteria of intoxication as defined above is not an expected or common side effect of these medications when used in prescribed amounts.[iii]

If a person is using a small amount of an opioid substance, such as the amount used for medicinal purposes, then this is considered permissible[iv]. However, If he is using a larger amount of it simply for the purpose of intoxication, euphoria or entertainment, then this is not permissible[v].  Therefore, drugs of abuse such as cocaine and heroine are not permissible to use because they are not used for medicinal purposes, but rather to achieve an altered mental state and euphoria.  It would not be unexpected for a person using these drugs of abuse to reach a state of intoxication as defined above.

In conclusion, opioid medications such as oxycodone and codeine are considered permissible to use if prescribed by a doctor for medical treatment. 

And Allah knows best

Mufti Adil Farooki, MD

Checked and approved by Mufti Abdul Muqtadir Sikander


[i]رد المحتار على الدر المختار – دار الفكر – 3:239

قَوْلُهُ أَوْ سَكْرَانَ) السُّكْرُ: سُرُورٌ يُزِيلُ الْعَقْلَ فَلَا يَعْرِفُ بِهِ السَّمَاءَ مِنْ الْأَرْضِ. وَقَالَ: بَلْ يَغْلِبُ عَلَى الْعَقْلِ فَيَهْذِي فِي كَلَامِهِ، وَرَجَّحُوا قَوْلَهُمَا فِي الطَّهَارَةِ وَالْأَيْمَانِ وَالْحُدُودِ

[ii] بدائع الصنائع في ترتيب الشرائع – دار الكتب العلمية – 5:118

قَوْلِهِمَا: شَهَادَةُ الْعُرْفِ وَالْعَادَةِ فَإِنَّ السَّكْرَانَ فِي مُتَعَارَفِ النَّاسِ اسْمٌ لِمَنْ هَذَى وَإِلَيْهِ أَشَارَ سَيِّدُنَا عَلِيٌّ – رَضِيَ اللَّهُ عَنْهُ – بِقَوْلِهِ: إذَا سَكِرَ هَذَى، وَإِذَا هَذَى افْتَرَى

[iii] https://www.drugs.com/sfx/percocet-side-effects.html

[iv] رد المحتار على الدر المختار – دار الفكر – 3:240

قَوْلُهُ أَوْ أَفْيُونٍ أَوْ بَنْجٍ) الْأَفْيُونُ: مَا يَخْرُجُ مِنْ الْخَشْخَاشِ. الْبَنْجُ: بِالْفَتْحِ نَبْتٌ مُنْبَتٌ. وَصَرَّحَ فِي الْبَدَائِعِ وَغَيْرِهَا بِعَدَمِ وُقُوعِ الطَّلَاقِ بِأَكْلِهِ مُعَلِّلًا بِأَنَّ زَوَالَ عَقْلِهِ لَمْ يَكُنْ بِسَبَبٍ هُوَ مَعْصِيَةٌ. وَالْحَقُّ التَّفْصِيلُ، وَهُوَ إنْ كَانَ لِلتَّدَاوِي لَمْ يَقَعْ لِعَدَمِ الْمَعْصِيَةِ، وَإِنْ لِلَّهْوِ وَإِدْخَالِ الْآفَةِ قَصْدًا فَيَنْبَغِي أَنْ لَا يَتَرَدَّدَ فِي الْوُقُوعِ

فَقَدْ فَرَّقَ بَيْنَ مَا إذَا كَانَ بِطَرِيقٍ مُحَرَّمٍ وَغَيْرِ مُحَرَّمٍ كَمَا تَرَى فَتَأَمَّلْ (قَوْلُهُ أَوْ بِمُبَاحٍ) كَمَا إذَا سَكِرَ مِنْ وَرَقِ الرُّمَّانِ فَإِنَّهُ لَا يَقَعُ طَلَاقُهُ وَلَا عَتَاقُهُ وَنَقَلَ الْإِجْمَاعَ عَلَى ذَلِكَ صَاحِبُ التَّهْذِيبِ كَذَا فِي الْهِنْدِيَّةِ ط. قُلْت: وَكَذَا لَوْ سَكِرَ بِبَنْجٍ أَوْ أَفْيُونٍ تَنَاوَلَهُ لَا عَلَى وَجْهِ الْمَعْصِيَةِ بَلْ التَّدَاوِي كَمَا مَرَّ

[v] رد المحتار على الدر المختار – دار الفكر – 4:42

وَفِي كَافِي الْحَاكِمِ مِنْ الْأَشْرِبَةِ: أَلَا تَرَى أَنَّ الْبَنْجَ لَا بَأْسَ بِتَدَاوِيهِ، وَإِذَا أَرَادَ أَنْ يَذْهَبَ عَقْلُهُ لَا يَنْبَغِي أَنْ يَفْعَلَ ذَلِكَ. اهـ.

وَبِهِ عُلِمَ أَنَّ الْمُرَادَ الْأَشْرِبَةُ الْمَائِعَةُ، وَأَنَّ الْبَنْجَ وَنَحْوَهُ مِنْ الْجَامِدَاتِ إنَّمَا يَحْرُمُ إذَا أَرَادَ بِهِ السُّكْرَ وَهُوَ الْكَثِيرُ مِنْهُ، دُونَ الْقَلِيلِ الْمُرَادُ بِهِ التَّدَاوِي وَنَحْوُهُ كَالتَّطَيُّبِ بِالْعَنْبَرِ وَجَوْزَةِ الطِّيبِ، وَنَظِيرُ ذَلِكَ مَا كَانَ سُمَيًّا قِتَالًا كَالْمَحْمُودَةِ وَهِيَ السَّقَمُونْيَا وَنَحْوُهَا مِنْ الْأَدْوِيَةِ السُّمِّيَّةِ فَإِنَّ اسْتِعْمَالَ الْقَلِيلِ مِنْهَا جَائِزٌ، بِخِلَافِ الْقَدْرِ الْمُضِرِّ فَإِنَّهُ يَحْرُمُ، فَافْهَمْ وَاغْتَنِمْ هَذَا التَّحْرِيرَ